1.37165

精脒

EMPROVE^® EXPERT

• 别名: 1,8-二氨基-4-氮杂辛烷, N-(3-氨基丙基)-1,4-丁烷
• 线性分子式: NH₂(CH₂)₃NH(CH₂)₄NH₂
• CAS号: 124-20-9
• 分子量: 145.25
• Beilstein: 1698591
• MDL號碼: MFCD00008229
• 分類程式碼代碼: 12352103
• 酶委員會索引編號: 204-689-0

属性

• 生物源: synthetic
• 品質等級: 500
• 等級: GMO free; GMP
• 描述: Aflatoxin-free; Melamin-free; DNase-free; RNase-free
• 產品線: EMPROVE^® EXPERT
• 雜質: low in endotoxins
• 折射率: n20/D 1.479 (lit.)
• 粒徑: (liquid or solidified mass)
• 密度: 0.925 g/mL at 25 °C (lit.)
• 應用: pharma/biopharma processes; pharmaceutical
• 儲存溫度: 15-25°C
• SMILES 字串: NCCCCNCCCN
• InChI: 1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2
• InChI 密鑰: ATHGHQPFGPMSJY-UHFFFAOYSA-N

说明

一般說明

Finding the right critical raw material that matches your quality expectation can be challenging. Especially if you are advancing through clinical phases, changing regulatory requirements can raise several questions.

As part of our EMPROVE^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

應用

Spermidine has several applications that are going beyond its chemical behavior as a base. The amino groups can interact with the phosphate groups of DNA and RNA and stabilize them. In addition, spermidine has a positive impact on transcription by RNA polymerases and can be found in several buffers. Within RNA bioprocessing, spermidine can be used for purification to bind and precipitate DNA. It may also be considered as adjuvant for mRNA vaccines.

The EMPROVE^® Expert quality grade provided with this product is tested for microbial and endotoxin levels and is RNase and DNase free. Stability studies according to ICH Q7 are running and stability conclusions will be available via EMPROVE^® Suite.

生化／生理作用

抑制神经元型一氧化氮合成酶（nNOS）。结合和沉淀DNA，可用于DNA结合蛋白纯化。激活T₄聚核苷酸激酶活性。

注意

如果需要无菌溶液，则应采用无菌过滤而非高压灭菌。时间一长，亚精胺将发生脱氨基作用；溶液应采用冷冻保存。通常需要配制新溶液。

法律資訊

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS05
• 訊號詞: Danger
• 危險聲明: H314
• 防範說明: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363 - P405
• 危險分類: Eye Dam. 1 - Skin Corr. 1B
• 儲存類別代碼: 8A - Combustible corrosive hazardous materials
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 233.6 °F - closed cup
• 閃點（°C）: 112 °C - closed cup