1.01544

L -精氨酸 单盐酸盐

EMPROVE^® EXPERT, Ph. Eur., BP, ChP, JP, USP

• 别名: (S)-(+)-2-氨基-5-[(氨基亚甲基)氨基]戊酸 单盐酸盐, (S)-(+)-精氨酸 盐酸盐
• 经验公式（希尔记法）: C₆H₁₄N₄O₂ · HCl
• CAS号: 1119-34-2
• 分子量: 210.66
• Beilstein: 3631658
• MDL號碼: MFCD00064550
• 分類程式碼代碼: 12352209
• 酶委員會索引編號: 214-275-1

属性

• agency: BP; ChP; JP; Ph. Eur.; USP
• 品質等級: 500
• 蒸汽壓力: <1 Pa ( 20 °C)
• 產品線: EMPROVE^® EXPERT
• 化驗: 98.5-101.0% dry basis (perchloric acid titration)
• 形狀: solid
• pH值: 5.7 (20 °C, 100 g/L in H₂O)
• mp: >235 °C
• 溶解度: water: 730 g/L at 20 °C
• 密度: 1.42 g/cm³ at 20 °C
• 負離子痕跡: chloride (Cl^-): 16.5-17.1%; sulfate (SO₄^2-): ≤200 ppm
• 正離子痕跡: As: ≤2 ppm; Fe: ≤10 ppm; NH₄⁺: ≤200 ppm; heavy metals (as Pb): ≤10 ppm
• 應用: liquid formulation; parenterals; pharma/biopharma processes; pharmaceutical
• 儲存溫度: 2-30°C
• SMILES 字串: Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
• InChI: 1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1
• InChI 密鑰: KWTQSFXGGICVPE-WCCKRBBISA-N

说明

一般說明

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

應用

Arginine hydrochloride has several applications in biopharma manufacturing such as an additive for protein refolding, aggregate suppression and buffer for chromatography.
Due to its low microbial and endotoxin limits, L-Arginine monohydrochloride Emprove^® Expert is suitable for high-risk applications.

生化／生理作用

一氧化氮合成酶的底物，可以转化为瓜氨酸和一氧化氮 (NO)。通过与一氧化氮相关的机理诱导胰岛素释放。

法律資訊

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable