09-874
Anti-SAP30 (yeast) Antibody
from rabbit
别名:
Sin3 corepressor complex subunit SAP30, Sin3-associated polypeptide, 30 kDa, Sin3-associated polypeptide, 30kDa, Sin3A-associated protein, 30kDa, histone deacetylase complex subunit SAP30
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所有图片(1)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
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生物源
rabbit
品質等級
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
Saccharomyces cerevisiae
技術
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
Saccharomyces cerevisiae ... Sap30(855305)
一般說明
SAP30 (Sin3A-associated protein) is a widely expressed nuclear protein that is functionally conserved between human and yeast. It is a component of the multiprotein histone deacetylase complex containing the transcriptional repressor Sin3, multiple histone deacetylases (HDAC1 and HDAC2), histone binding proteins (RbAp46 and RbAp48) and other polypeptides. SAP30 can recruit the deacetylase complex to promoter DNA in a Sin3 independent manner and is involved in the recruitment of the mSin3 complex to a specific subset of N-CoR corepressor complexes. The latter function suggests a role for SAP30 in N-CoR-mediated repression. Furthermore, SAP30 may be involved in imparting target specificity to the deacetylase complex.
特異性
Not tested in other species.
Recognizes yeast SAP30 at ~27 kDa.
免疫原
Epitope: a.a. 141-157
Immunogen was a synthetic peptide corresponding to a.a. 141-157 of yeast SAP30, conjugated to KLH.
應用
Anti-SAP30 (yeast) Antibody is a Rabbit Polyclonal Antibody for detection of SAP30 (yeast) also known as Sin3 corepressor complex subunit SAP30 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Histones
Chromatin Biology
Histones
Chromatin Biology
品質
Western Blot Analysis:
1 μg/ml of this antibody detected SAP30 in a yeast extract.
1 μg/ml of this antibody detected SAP30 in a yeast extract.
標靶描述
~27 kDa
外觀
Format: Purified
Protein A purified IgG in 0.1M Tris-Glycine (pH7.4) 150 mM NaCl with 0.05% NaN3.
儲存和穩定性
Stable for 1 year at 2-8°C from date of shipment.
分析報告
Control
Yeast extract
Yeast extract
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
Specific initiation by RNA polymerase I in a whole-cell extract from yeast.
Schultz, M C, et al.
Proceedings of the National Academy of Sciences of the USA, 88, 1004-1008 (1991)
Y Zhang et al.
Molecular cell, 1(7), 1021-1031 (1998-07-04)
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Recently, histone acetylation and deacetylation were found to be catalyzed by structurally distinct, multisubunit complexes that mediate, respectively, activation and repression of transcription. Here, we identify SAP30
C D Laherty et al.
Molecular cell, 2(1), 33-42 (1998-08-14)
The transcriptional corepressor mSin3 is found in a large multiprotein complex containing the histone deacetylases HDAC1 and HDAC2, in addition to at least five tightly associated polypeptides. We have cloned and characterized a novel component of the mSin3 complex, SAP30
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