推荐产品
生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
human
製造商／商標名
Upstate®
技術
ChIP: suitable (ChIP-seq)
dot blot: suitable
inhibition assay: suitable (peptide)
multiplexing: suitable
western blot: suitable
同型
IgG
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
acetylation (Lys 4)
基因資訊
human ... H3F3B(3021)
特異性
组蛋白H3在Lys4上乙酰化时
预计具有广泛的物种交叉反应性
免疫原
KLH偶联合成肽包含序列 ...RT[AcK]Q...，其中[AcK]对应于人组蛋白H3的乙酰赖氨酸4
應用
建议的稀释度：
蛋白质印迹：1:1000 - 1:10,000
蛋白质印迹：1:1000 - 1:10,000
抗乙酰基组蛋白H3（Lys 4）抗体是一种兔多克隆抗体，用于检测乙酰基组蛋白H3（Lys 4），也称为H3K4Ac，组蛋白H3（乙酰基K4）& 已在Mplex、WB、PIA、ChIP、ChIP-seq、DB中得到验证。
研究子类别
组蛋白
组蛋白
研究类别
表观遗传学&核功能
表观遗传学&核功能
品質
已通过免疫印迹进行常规评估。
標靶描述
Mr ~17kDa
外觀
100 μL免疫亲和纯化的兔IgG，溶于在含有0.1 M Tris-甘氨酸（pH 7.4）和0.15 M NaCl，并含有0.05%叠氮化钠和30%甘油的缓冲液中
免疫亲和纯化
儲存和穩定性
自运送之日起在-20°C下保存1年
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Federico Forneris et al.
The Journal of biological chemistry, 281(46), 35289-35295 (2006-09-22)
Human lysine-specific demethylase (LSD1) is a chromatin-modifying enzyme that specifically removes methyl groups from mono- and dimethylated Lys4 of histone H3 (H3-K4). We used a combination of in vivo and in vitro experiments to characterize the substrate specificity and recognition
Sarah Javaid et al.
Cell reports, 5(6), 1679-1689 (2013-12-24)
Epithelial-mesenchymal transition (EMT) is thought to contribute to cancer metastasis, but its underlying mechanisms are not well understood. To define early steps in this cellular transformation, we analyzed human mammary epithelial cells with tightly regulated expression of Snail-1, a master
Flore Beurton et al.
Nucleic acids research, 47(21), 11164-11180 (2019-10-12)
The CFP1 CXXC zinc finger protein targets the SET1/COMPASS complex to non-methylated CpG rich promoters to implement tri-methylation of histone H3 Lys4 (H3K4me3). Although H3K4me3 is widely associated with gene expression, the effects of CFP1 loss vary, suggesting additional chromatin
Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo.
Beconi, M; Aziz, O; Matthews, K; Moumne, L; O'Connell, C; Yates, D; Clifton, S; Pett et al.
Testing null
Histone H3k9 and H3k27 Acetylation Regulates IL-4/STAT6-Mediated Igε Transcription in B Lymphocytes.
Xiao Fu et al.
Anatomical record (Hoboken, N.J. : 2007), 298(8), 1431-1439 (2015-05-09)
IL-4 activates STAT6 and causes the subsequent up-regulation of Ig heavy chain germline Igε via chromatin remodeling involved in B lymphocytes development. STAT6 acts as a molecular switch to regulate the higher-order chromatin remodeling via dynamically orchestrating co-activators (CBP/Tudor-SN) and
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