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Key Documents

07-1491

Sigma-Aldrich

Anti-Calcineurin pan A Antibody

from rabbit, purified by affinity chromatography

别名:

CAM-PRP catalytic subunit, Calmodulin-dependent calcineurin A subunit alpha isoform, calcineurin A alpha, protein phosphatase 3 (formerly 2B), catalytic subunit,

alpha isoform, protein phosphatase 3 (formerly 2B), catalytic subunit,

alp

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

rabbit

品質等級

100
200

共軛

conjugate

抗體表格

affinity isolated antibody

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

liquid

純化經由

affinity chromatography

物種活性

human, rat, mouse

物種活性(以同源性預測)

mammals (based on 100% sequence homology)

技術

western blot: suitable

免疫原序列

KLH-conjugated synthetic peptide corresponding to Calcineurin.

NCBI登錄號

UniProt登錄號

運輸包裝

wet ice

儲存溫度

−20°C

一般說明

Calcineurin is a serine/threonine protein phosphatase involved in the mediation of signal tranduction in a wide variety of cellular responses. Calcineurin has been linked to Pmk1 MAP kinase and PI pathways, as well as to members of the small GTPase Rab/Ypt family and Type II myosin. Furthermore, calcineurin participates in the transduction of extracellular signals to the nucleus by dephosphorylation of members of the NFAT family of transcription factors. These linkages demonstrate calcineurin′s multifunctional capabilities in the regulation of calcium signaling.

特異性

This antibody recognizes both the Aα and Aβ, the major catalytic subunit gene isoforms of calcineurin in most tissues; may also react with the testis form, Aγ. This antibody has very high sensitivity and specificity, which allow detection of calcineurin in tissues where expression is low, such as lymphoid tissue. Reacts with calcineurin of all mammalian species.

免疫原

KLH-conjugated synthetic peptide corresponding to Calcineurin.

應用

Detect Calcineurin pan A using this Anti-Calcineurin pan A Antibody validated for use in WB.
Research Category
Signaling
Research Sub Category
GPCR, cAMP/cGMP & Calcium Signaling

品質

Evaluated by Western Blot in Mouse brain lysate.
Western Blot Analysis: 1:1,000 dilution of this antibody detected Calcineurin on 10 µg of mouse brain lysate.

標靶描述

~58 kDa

聯結

Replaces: AB1695

外觀

Affinity purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH7.4) 150 mM NaCl with 40% gylerol. Contains no preservative.

儲存和穩定性

Store at -20°C for up to 12 months in undiluted aliquots; at this temperature the solution will
remain unfrozen.

分析報告

Control
Mouse brain lysate

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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