07-1387
抗氧化-CaM激酶II（Met281/282）抗体
serum, from rabbit
别名:
CAMKK beta protein, CaM-KK beta, CaM-kinase kinase beta, CaMKK beta, Calcium/calmodulin-dependent protein kinase kinase beta, calcium/calmodulin-dependent protein kinase beta, calcium/calmodulin-dependent protein kinase kinase 2 beta, calcium/calmodulin-
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所有图片(2)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
rabbit
品質等級
抗體表格
serum
抗體產品種類
primary antibodies
無性繁殖
polyclonal
物種活性
mouse, rat, human
技術
immunocytochemistry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
human ... CAMK2D(817)
一般說明
Ca2+/钙调蛋白依赖性激酶家族包括CaM激酶I至IV，磷酸化酶激酶和MLCK。在没有刺激的情况下，CaM激酶是无活性的。与Ca2+/钙调蛋白的结合诱导构象变化和激活。CaM激酶具有广泛的底物特异性，具有许多细胞功能。
特異性
基于与免疫原序列的100%同源性，预期在小鼠和大鼠中发生交叉反应。
当在Met281/282上氧化时，该抗体可识别CaM激酶II。
免疫原
包含并包括氧化的Met281/282的合成肽。
表位：氧化Met281/282
應用
一个独立的实验室验证了该抗体在用盐水，AngII或Iso处理的小鼠心脏切片中的免疫细胞化学中起作用（Erickson，J.R.，2008）。
经验证，该抗氧化CaM激酶II（Met281/282）抗体可用于WB，IC检测氧化CaM激酶II（Met281/282）。
品質
通过蛋白质印迹在未处理和经H2O2处理的小鼠心脏细胞裂解液中进行了评估。
蛋白质印迹分析： 该抗体的1:1,000稀释液用于检测小鼠心脏细胞裂解液中氧化的CaM激酶II。
蛋白质印迹分析： 该抗体的1:1,000稀释液用于检测小鼠心脏细胞裂解液中氧化的CaM激酶II。
標靶描述
60 kDa
聯結
替代：04-1079
儲存和穩定性
自收到之日起，在-20°C条件下可稳定保存1年。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。
处理建议：收到后，在取下瓶盖之前，将小瓶离心并轻轻混合溶液。
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
Ichiro Matsuo et al.
PloS one, 17(6), e0258823-e0258823 (2022-06-02)
Oral infections, particularly periodontitis, are a well-established risk factor for cardiovascular diseases, although the molecular mechanisms involved remain elusive. The aims of the present study were to investigate the effects of lipopolysaccharide derived from Porphyromonas gingivalis (PG-LPS) on cardiac function
Shuo Geng et al.
Science advances, 5(2), eaav2309-eaav2309 (2019-02-19)
Nonresolving inflammation perpetuated by innate leukocytes is involved in the pathogenesis of unstable atherosclerosis. However, the role and regulation of neutrophils related to nonresolving inflammation and atherosclerosis are poorly understood. We report herein that chronic subclinical endotoxemia, a risk factor
Gabrielle Fredman et al.
Nature communications, 7, 12859-12859 (2016-09-24)
Chronic unresolved inflammation plays a causal role in the development of advanced atherosclerosis, but the mechanisms that prevent resolution in atherosclerosis remain unclear. Here, we use targeted mass spectrometry to identify specialized pro-resolving lipid mediators (SPM) in histologically-defined stable and
Patricia Rouet-Benzineb et al.
Physiological reports, 6(21), e13912-e13912 (2018-11-16)
We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive
Rohan Varshney et al.
International journal of molecular sciences, 22(4) (2021-03-07)
Free radicals, or reactive oxygen species, have been implicated as one of the primary causes of myocardial pathologies elicited by chronic diseases and age. The imbalance between pro-oxidants and antioxidants, termed "oxidative stress", involves several pathological changes in mouse hearts
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