07-1341
抗PHLPP1抗体
from rabbit, purified by affinity chromatography
别名:
PH domain and leucine rich repeat protein phosphatase, PH domain leucine-rich repeat protein phosphatase, Pleckstrin homology domain-containing family E protein 1, SCN circadian oscillatory protein, Suprachiasmatic nucleus circadian oscillatory protein
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所有图片(3)
About This Item
分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41
推荐产品
生物源
rabbit
品質等級
共軛
conjugate
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
liquid
純化經由
affinity chromatography
物種活性
rat, mouse, human
技術
immunocytochemistry: suitable
western blot: suitable
免疫原序列
KLH-conjugated linear peptide corresponding to the C-terminus of PHLPP1.
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
基因資訊
human ... PHLPP1(23239)
一般說明
PHLPP1是负责Akt (Ser473)位点去磷酸化的蛋白磷酸酶。Akt (Ser473)是TORC2 (mTOR)磷酸化激活位点。
特異性
该抗体可识别PHLPP1的C端。
免疫原
KLH偶联的线性肽，对应于PHLPP1的C端。
表位：C端
應用
抗PHLPP1抗体检测PHLPP1的水平 & 已发布 & 经验证可用于WB & IC。
研究子类别
PI3K、Akt & mTOR 信号传导
PI3K、Akt & mTOR 信号传导
研究类别
信号传导
信号传导
品質
通过蛋白质印迹在人脑组织裂解物中进行了评估。
蛋白质印迹分析：该抗体的1：1,000稀释液可在人脑组织裂解液中检测到PHLPP1。
蛋白质印迹分析：该抗体的1：1,000稀释液可在人脑组织裂解液中检测到PHLPP1。
標靶描述
134 kDa 在110 kDa下观察
外觀
亲和纯化
纯化的兔血清，溶于含有0.1 M Tris-甘氨酸（pH 7.4）、150 mM NaCl和0.05％叠氮化钠的缓冲液中。
儲存和穩定性
自接收之日起，在2-8°C下冷藏保存1年。
分析報告
对照
人脑组织裂解液
人脑组织裂解液
其他說明
浓度：请参考批次特异性浓缩物的检验报告。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Saida Abdelli et al.
PloS one, 7(5), e35997-e35997 (2012-05-09)
We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects. While it is known that JNK1 or JNK2 may
A molecular brake controls the magnitude of long-term potentiation.
Wang, Y; Zhu, G; Briz, V; Hsu, YT; Bi, X; Baudry, M
Nature Communications null
Julia Fischer et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(33), 16551-16560 (2019-07-28)
The dynamic interplay between metabolism and immune responses in health and disease, by which different immune cells impact on metabolic processes, are being increasingly appreciated. However, the potential of master regulators of metabolism to control innate immunity are less understood.
Marcelline K Hanson et al.
PloS one, 16(6), e0251732-e0251732 (2021-06-19)
Prior studies demonstrated that deletion of the protein phosphatase Phlpp1 in Ctsk-Cre expressing cells enhances bone mass, characterized by diminished osteoclast activity and increased coupling to bone formation. Due to non-specific expression of Ctsk-Cre, the definitive mechanism for this observation
Yubin Wang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(48), 18880-18892 (2013-11-29)
Prolonged calpain activation is widely recognized as a key component of neurodegeneration in a variety of pathological conditions. Numerous reports have also indicated that synaptic activation of NMDA receptors (NMDARs) provides neuroprotection against a variety of insults. Here, we report
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