07-1216

Anti-PP2A Antibody, Catalytic subunit

Upstate^®, from rabbit

• 别名: Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, delta isoform, Delta isoform of regulatory subunit B56, protein phosphatase, Protein phosphatase 2, regulatory subunit B (B56), delta isoform, Protein phosphatase 2, regulatory subunit B
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

属性

• 生物源: rabbit
• 品質等級: 100
• 抗體表格: affinity purified immunoglobulin
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 純化經由: affinity chromatography
• 物種活性: mouse, chicken, bovine, rat, human
• 製造商／商標名: Upstate^®
• 技術: immunohistochemistry: suitable (paraffin); western blot: suitable
• 同型: IgG
• NCBI登錄號: NM_006245
• UniProt登錄號: Q14738
• 運輸包裝: dry ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... PPP2R5D(5528)

说明

一般說明

PP2A is a type 2 protein Ser/Thr phosphatase characterized by high activity against the α subunit of Phosphorylase Kinase and low sensitivity to Inhibitor-2. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and its high sensitivity to Okadaic Acid. It is also thought to be the principal downmodulator of Ser/Thr kinase cascades. PP2A is a heterotrimer containing a structural subunit (A), a regulatory subunit (B), and a catalytic subunit (C). There are multiple isotypes (encoded by distinct genes) of the B subunit, grouped into three families: B/PR55, B′/PR61, and B′′/PR72 . PTPA is a member of the B′ family that is required for activation of PP2A by an undefined mechanism.

特異性

Peptide is highly conserved in human, rat, bovine, mouse and chicken.

Recognizes protein phosphatase 2A, catalytic subunit.

免疫原

Epitope: C-terminus

Synthetic peptide corresponding to a.a. 298-309 of the human sequence.

應用

Immunohistochemisty (paraffin): Antibody was diluted to 1:100, using IHC-Select Detection with HRP-DAB. Immunoreactivity is seen as staining in normal human testis.

Research Category
Signaling

Research Sub Category
Kinases & Phosphatases

This Anti-PP2A Antibody, Catalytic subunit is validated for use in WB, IH(P) for the detection of PP2A.

品質

Routinely evaluated by Western Blot on HEK293 lysates.
Western Blot Analysis:
1:500-1:1,000 dilution is traditonally used to detected PP2A, Catalytic subunit in 10 μg of HEK293 lysates.

標靶描述

60 kDa

聯結

Replaces: AB1621

外觀

Affinity purified

Purified rabbit polyclonal IgG in buffer containing PBS with no preservatives.

儲存和穩定性

Stable for 1 year at -80°C from date of receipt. Avoid repeated freeze/thaw.

分析報告

Control
HEK293 cell lysate

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全信息

• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable