05-23-0500

Bradykinin

Induces the release of nitric oxide.

• 别名: Bradykinin, Kallidin, RPPGFSPFR, callidin
• 经验公式（希尔记法）: C₅₀H₇₃N₁₅O₁₁
• CAS号: 58-82-2
• 分子量: 1060.21
• 分類程式碼代碼: 12352202
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white to off-white
• 溶解度: 5% acetic acid: 1 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C50H73N15O11/c51-32(16-7-21-56-49(52)53)45(72)65-25-11-20-39(65)47(74)64-24-9-18-37(64)43(70)58-28-40(67)59-34(26-30-12-3-1-4-13-30)41(68)62-36(29-66)46(73)63-23-10-19-38(63)44(71)61-35(27-31-14-5-2-6-15-31)42(69)60-33(48(75)76)17-8-22-57-50(54)55/h1-6,12-15,32-39,66H,7-11,16-29,51H2,(H,58,70)(H,59,67)(H,60,69)(H,61,71)(H,62,68)(H,75,76)(H4,52,53,56)(H4,54,55,57)/t32-,33-,34-,35-,36-,37-,38-,39-/m0/s1
• InChI 密鑰: QXZGBUJJYSLZLT-FDISYFBBSA-N

说明

一般說明

Bradykinin, a nonapeptide, is produced in plasma under inflammatory conditions by cleavage of kininogen by kallikrein. Bradykinin is involved in a number of physiological functions, including the release of nitric oxide, stimulation of pain receptors, induction of antimitogenic effects, inhibition of cAMP accumulation, induction of smooth muscle contraction, and vasodilation, as well as in inflammation processes. Also involved in edema resulting from trauma or injury. Improves post-ischemic recovery of the heart via a nitric oxide-dependent mechanism.

應用

Bradykininhas been used in studying the changes in colonic afferent response tobradykinin.

生化／生理作用

Cell permeable: no

Primary Target
Induces the release of nitric oxide

Product does not compete with ATP.

Reversible: no

包裝

Yes

序列

H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH

外觀

Supplied as an acetate salt.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Mombouli, J.V., and Vanhoutte, P.M. 1995. Am. J. Hypertens.8, 195.
Zhu, P., et al. 1995. Cardiovasc. Res.29, 658.
Bedarida, G.V., et al. 1994. Horm. Metab. Res. 26, 109.
Altiok, N., and Fredholm, B.B. 1993. Cell Signal. 5, 279.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable