推荐产品
等級
certified reference material
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
100 μg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
forensics and toxicology
格式
single component solution
儲存溫度
−20°C
SMILES 字串
O=C(OC)/C([C@H]1C[C@@](N(C[C@H]1CC)CC2)([H])C3=C2C(C(OC)=CC=C4)=C4N3)=C/OC
InChI
1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16+,19+/m1/s1
InChI 密鑰
LELBFTMXCIIKKX-QVRQZEMUSA-N
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一般說明
Mitragynine, commonly known as Kratom, is the most abundant alkaloid in the plant Mitragynine speciosa. Sold over the internet as herbal plant extracts, Kratom is noted for its psychoactive, stimulant, and sedative effects depending on the dosage level. According to DEA′s Drugs and Chemicals of Concern page, mitragynine use can lead to addiction with adverse effects ranging from anorexia and weight loss to hallucinations and delusion.
應用
- Pharmacokinetic Interaction of Kratom and Cannabidiol: A study analyzed the pharmacokinetic interactions between mitragynine and cannabidiol in male rats, providing critical insights for co-administration of these compounds (Berthold et al., 2024).
- Enhancement of Low-Dose Doxorubicin Cytotoxicity by Kratom Extracts: Research investigated whether kratom extracts enhance the cytotoxic effects of low-dose doxorubicin against lung cancer cells, suggesting a potential use of mitragynine in cancer therapy (Bayu et al., 2024).
- Extraction and Detection of Mitragynine: A technique using high-performance liquid chromatography for the extraction and detection of mitragynine from Kratom leaves was developed, enhancing the accuracy and efficiency of mitragynine isolation for research purposes (Ng and Ha, 2024).
- Amelioration of Mitragynine Withdrawal Symptoms: A study explored the potential of an epigenetic mechanism to ameliorate withdrawal behavior and cognitive impairments caused by mitragynine, contributing to better management strategies for opioid withdrawal symptoms (Yunusa et al., 2024).
- Imaging Mass Spectrometry Analysis of Mitragynine: Research utilized MALDI imaging mass spectrometry to study the distribution of Mitragyna speciosa alkaloids, including mitragynine, in dosed rat brain tissue, advancing the understanding of its biochemical behavior (Liang et al., 2024).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
標靶器官
Eyes,Central nervous system
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
Justin M Holler et al.
Journal of analytical toxicology, 35(1), 54-59 (2011-01-12)
A death involving abuse of propylhexedrine and mitragynine is reported. Propylhexedrine is a potent α-adrenergic sympathomimetic amine found in nasal decongestant inhalers. The decedent was found dead in his living quarters with no signs of physical trauma. Analysis of his
Friedrich G Kapp et al.
Journal of medical toxicology : official journal of the American College of Medical Toxicology, 7(3), 227-231 (2011-04-30)
Kratom (Mitragyna speciosa) is a common medical plant in Thailand and is known to contain mitragynine as the main alkaloid. According to an increase in published reports and calls at German poison control centers, it has been used more frequently
Zulkhurnain Utar et al.
Journal of ethnopharmacology, 136(1), 75-82 (2011-04-26)
[corrected] Mitragyna speciosa Korth (Rubiaceae) is one of the medicinal plants used traditionally to treat various types of diseases especially in Thailand and Malaysia. Its anti-inflammatory and analgesic properties in its crude form are well documented. In this study, the
[Krypton--new, deadly Internet drug. Since October 2009 have nine young persons died in Sweden].
Björn G Bäckstrom et al.
Lakartidningen, 107(50), 3196-3197 (2011-02-08)
Juraithip Wungsintaweekul et al.
Biotechnology letters, 34(10), 1945-1950 (2012-06-21)
Mitragynine is a pharmacologically-active terpenoid indole alkaloid found in Mitragyna speciosa leaves. Treatment with methyl jasmonate (10 μM) for 24 h and yeast extract (0.1 mg/ml) for 12 h were the optimum conditions of elicitation of mitragynine accumulation in a
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