R0875

利血平

• 别名: (3β, 16β, 17α, 18β, 20α)-11,17-二甲氧基-18-[(3,4,5-三甲氧基苯甲酰基)氧基]育亨烷-16-羧酸甲酯
• 经验公式（希尔记法）: C₃₃H₄₀N₂O₉
• CAS号: 50-55-5
• 分子量: 608.68
• Beilstein: 102014
• EC號碼: 200-047-9
• MDL號碼: MFCD00005091
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24278208
• NACRES: NA.77

属性

• mp: ~265 °C (dec.)
• SMILES 字串: CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
• InChI: 1S/C33H40N2O9/c1-38-19-7-8-20-21-9-10-35-16-18-13-27(44-32(36)17-11-25(39-2)30(41-4)26(12-17)40-3)31(42-5)28(33(37)43-6)22(18)15-24(35)29(21)34-23(20)14-19/h7-8,11-12,14,18,22,24,27-28,31,34H,9-10,13,15-16H2,1-6H3/t18-,22+,24-,27-,28+,31+/m1/s1
• InChI 密鑰: QEVHRUUCFGRFIF-MDEJGZGSSA-N
• 基因資訊: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC18A2(6571)

说明

應用

Reserpine has been used:

• to study its effect on minimal inhibitory concentration of trovafloxacin and ciprofloxacin
• inject rats, to study its effect on behavioural parameters such as locomotion and fear/anxiety
• as a lock spray reference compound in lipid profiling

生化／生理作用

Reserpine is an alkaloid present in Rauwolfia species. It is useful in treating systemic hypertension, schizophrenia, psychiatric disorders and Raynaud′s syndrome. Reserpine is known to inhibit adrenaline induced-cutaneous blood vessel constriction. It diminishes the effect of hyperthyroidism on cardiovascular and nervous system.

抑制儿茶酚胺和血清素的囊泡摄取。

特點和優勢

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全信息

• 象形圖: GHS08,GHS07
• 訊號詞: Danger
• 危險聲明: H302,H336,H351,H360D
• 防範說明: P201 - P301 + P312 + P330 - P308 + P313
• 危險分類: Acute Tox. 4 Oral - Carc. 2 - Repr. 1A - STOT SE 3
• 標靶器官: Central nervous system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Faceshields, Gloves