H-110

Hydroxyitraconazole

100 μg/mL in methanol, certified reference material, Cerilliant^®

• 经验公式（希尔记法）: C₃₅H₃₈Cl₂N₈O₅
• CAS号: 112559-91-8
• 分子量: 721.63
• 分類程式碼代碼: 41116107
• NACRES: NA.24

属性

• 等級: certified reference material
• 品質等級: 300
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 100 μg/mL in methanol
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: clinical testing
• 形式: single component solution
• 儲存溫度: −20°C
• InChI: 1S/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3
• InChI 密鑰: ISJVOEOJQLKSJU-UHFFFAOYSA-N

说明

一般說明

Hydroxyitraconazole is an active metabolite of itraconazole, an antifungal drug used for the treatment of fungal infections. Therapeutic drug monitoring of hydroxyitraconazole is utilized in the management of patients receiving itraconazole to ensure therapeutic levels of the drug have been achieved. This Certified Spiking Solution^® is suitable as starting material for calibrators, controls, or linearity standards for therapeutic drug monitoring or clinical and diagnostic testing of hydroxyitraconazole in patient blood, serum, or plasma samples by HPLC or LC-MS/MS.

應用

• Hydroxyitraconazole Antifungal Research: Utilized prominently in antifungal research, Hydroxyitraconazole serves as a potent inhibitor in studies targeting resistant fungal strains, contributing significantly to the development of more effective antifungal therapies (Krug et al., 2023).


• Itraconazole Metabolite Study: As a major metabolite of itraconazole, Hydroxyitraconazole is crucial in pharmacokinetic studies to understand the metabolism of itraconazole, aiding in optimizing dosing for better therapeutic outcomes (Miljković et al., 2022).


• Pharmaceutical Research Chemicals: This compound is pivotal in pharmaceutical research, providing insights into the drug′s behavior in biological systems and its interaction with other pharmacological agents, thereby facilitating drug development and safety evaluations (Iwasaki et al., 2019).


• Antifungal Drug Discovery: Integral to antifungal drug discovery, Hydroxyitraconazole aids in screening and developing new drug candidates, especially those targeting difficult-to-treat infections, thus expanding the arsenal against global fungal threats (Müller et al., 2017).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形圖: GHS02,GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H225,H301 + H311 + H331,H370
• 防範說明: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• 標靶器官: Eyes
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup