860811P

12:0(2R-OH) Ceramide

Avanti Research^™ - A Croda Brand 860811P, powder

• 别名: N-(2′-(R)-hydroxylauroyl)-D-erythro-sphingosine
• 经验公式（希尔记法）: C₃₀H₅₉NO₄
• CAS号: 1246298-44-1
• 分子量: 497.79
• MDL號碼: MFCD22416669
• 分類程式碼代碼: 12352211
• NACRES: NA.25

属性

• 形狀: powder
• 包裝: pkg of 1 × 5 mg (860811P-5mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 860811P
• 脂質類型: sphingolipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@H](O)CCCCCCCCCC)=O)CO
• InChI: 1S/C30H59NO4/c1-3-5-7-9-11-13-14-15-16-17-19-20-22-24-28(33)27(26-32)31-30(35)29(34)25-23-21-18-12-10-8-6-4-2/h22,24,27-29,32-34H,3-21,23,25-26H2,1-2H3,(H,31,35)/b24-22+/t27-,28+,29+/m0/s1
• InChI 密鑰: CPDJNFOAARXMMT-XOVVVQEXSA-N

说明

一般說明

Ceramides containing 2-hydroxy fatty acid (hFA) are found primarily in the epidermis. 12:0(2R-OH) Ceramide is a 2R hydroxylated lauric acid-containing ceramide.

生化／生理作用

Hydroxy fatty acid (hFA)-sphingolipids play a specific role in cell signaling. Synthesis of hFA-ceramides requires fatty acid 2-hydroxylase (FA2H). Mutations of this key enzyme are associated with the development of nervous system disorders such as leukodystrophy and spastic paraparesis in humans. hFA-ceramides are essential for the epidermal permeability barrier function. The mechanism of action for an antitumor drug, PM02734 involves hFA-ceramides in the cell membrane.

包裝

5 mL Amber Glass Screw Cap Vial (860811P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3