860508P

C8 Ceramide (d18:1/8:0)

Avanti Research^™ - A Croda Brand 860508P, powder

• 别名: N-octanoyl-D-erythro-sphingosine
• 经验公式（希尔记法）: C₂₆H₅₁NO₃
• CAS号: 74713-59-0
• 分子量: 425.69
• MDL號碼: MFCD00236496
• 分類程式碼代碼: 12352211
• NACRES: NA.25

属性

• 形狀: powder
• 包裝: pkg of 1 × 5 mg (860508P-5mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 860508P
• 脂質類型: sphingolipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC
• InChI: 1S/C26H51NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h19,21,24-25,28-29H,3-18,20,22-23H2,1-2H3,(H,27,30)/b21-19+/t24-,25+/m0/s1
• InChI 密鑰: APDLCSPGWPLYEQ-WRBRXSDHSA-N

说明

一般說明

C8 Ceramide is a short chain ceramide and is cell permeable.

應用

C8 Ceramide (d18:1/8:0) has been used as an internal ceramide standard in electrospray ionization. It has also been used as a substrate for ceramide kinase activity assay. It is suitable for use as a substrate for galactocerebrosidase.

生化／生理作用

C8 Ceramide has anti-tumor functionality. Synthetic liposomal C8 ceramide inhibits hepatocellular carcinoma (HCC). Addition of exogenous C8 ceramide causes necrosis in hepatocytes by decreasing ATP levels and impairing mitochondrial functionality. C8 ceramide inhibition of serine palmitoyl transferase halts de novo sphingolipid biosynthesis. It also acts as chemotherapeutic agent by increasing the reactive oxygen species in lung cancer cells.

包裝

5 mL Amber Glass Screw Cap Vial (860508P-5mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全信息

• 儲存類別代碼: 11 - Combustible Solids