推荐产品
形狀
powder
包裝
pkg of 1 × 5 mg (860626P-5mg)
製造商／商標名
Avanti Research™ - A Croda Brand 860626P
脂質類型
sphingolipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
OC[C@]([H])(NC(CCCCCCC)=O)[C@]([H])(O)CCCCCCCCCCCCCCC
InChI
1S/C26H53NO3/c1-3-5-7-9-10-11-12-13-14-15-16-18-19-21-25(29)24(23-28)27-26(30)22-20-17-8-6-4-2/h24-25,28-29H,3-23H2,1-2H3,(H,27,30)/t24-,25+/m0/s1
InChI 密鑰
LGOFBZUQIUVJFS-LOSJGSFVSA-N
應用
C8 Dihydroceramide (d18:0/8:0) has been used as an internal standard to quantify the lipid extracted from human plasma by liquid chromatography mass spectrometry during high-throughput plasma lipidomics.
生化／生理作用
C8 Dihydroceramide (d18:0/8:0) or N-octanoyl-D-erythro-sphinganine, is a synthetic dihydroceramide. Dihydroceramide acts as a precursor for de-novo ceramide synthesis. C8 Dihydroceramide mimics γ-tocotrienol (γTE) in stimulating NF-κB-target protein A20 expression, increasing endoplasmic reticulum (ER) stress and reducing tumor necrosis factor (TNF)-triggered nuclear factor kappa B (NF-κB) activation.
包裝
5 mL Amber Glass Screw Cap Vial (860626P-5mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Jennifer T Saville et al.
Journal of inherited metabolic disease (2019-11-11)
Gaucher disease (GD) is an inherited metabolic disorder characterised by impaired catabolism of the glycosphingolipid, glucosylceramide. The deacetylated derivative, glucosylsphingosine (GluSph, lyso-Gb1) has materialised as a biomarker for GD. Further appraisal of the clinical utility of GluSph is required in
Vitamin E gamma-tocotrienol inhibits cytokine-stimulated NF-kappaB activation by induction of anti-inflammatory A20 via stress adaptive response due to modulation of sphingolipids
Wang Y, et al.
Journal of Immunology, 195(1), 126-133 (2015)
High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors
Huynh K, et al.
Cell Chemical Biology, 26(1), 71-84 (2019)
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