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描述
1-palmitoyl-2-hydroxy-sn-glycero-3-phosphate (sodium salt)
化驗
>99% (LPA; may contain up to 10% of the 2-LPA isomer, TLC)
形狀
powder
包裝
pkg of 1 × 200 mg (857123P-200mg)
pkg of 1 × 25 mg (857123P-25mg)
製造商／商標名
Avanti Research™ - A Croda Brand
脂質類型
phospholipids
cardiolipins
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
溶血磷脂酸（LPA）属于磷脂类，其甘油主链由磷酸基、脂肪链和羟基连接而成。它的磷酸基连接到sn-3位，脂肪链连接到sn-1或sn-2位，羟基连接到其余sn-1或sn-2位。
應用
16:0 Lyso PA适合用作从卵巢癌患者血浆样品中提取脂质的内标。它也适合于制备用于合成脂质体的脂质溶液。
生化／生理作用
溶血磷脂酸（LPA）参与多种生物学功能。它是检测卵巢癌的潜在生物标志物。LPA可刺激血小板聚集、平滑肌收缩、趋化、细胞骨架重排、Ca2+动员、神经递质释放和细胞增殖。棕榈酰溶血磷脂酸会增加二磷酸腺苷（ADP）刺激的聚集。
包裝
5 mL棕色玻璃螺旋盖样品瓶（857123P-200mg）
5 mL棕色玻璃螺旋盖样品瓶（857123P-25mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
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The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling
Koprivanacz K, et al.
Cellular Signalling, 32(1-2), 66-75 (2017)
Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets
Benton AM, et al.
Blood, 60(3), 642-649 (1982)
Maya Sawada et al.
Langmuir : the ACS journal of surfaces and colloids, 36(17), 4671-4681 (2020-04-10)
Amyloid fibrils are formed by denatured proteins when the supersaturation of denatured proteins is broken by agitation, such as ultrasonication, or by seeding, although the detailed mechanism of how solubility and supersaturation regulate amyloid formation remains unclear. To further understand
Olaposi I Omotuyi et al.
Scientific reports, 5, 13343-13343 (2015-08-14)
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has
Qingxin Shi et al.
Food & function, 10(12), 7782-7792 (2019-11-30)
Triterpenoid saponins from Kuding tea have demonstrated preventive effects on hyperlipidaemia induced by a high-fat diet. Lysoglycerophospholipids (Lyso-GPLs) are known to be associated with proatherogenic conditions such as hyperlipidaemia. In this study, a target profiling strategy based on a multiple
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