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化驗
>99% (LPI; may contain up to 10% of the 2-LPI isomer, TLC)
形狀
powder
包裝
pkg of 1 × 100 μg (with stopper and crimp cap (850102P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850102P-500ug))
製造商／商標名
Avanti Polar Lipids 850102P
脂質類型
phosphoglycerides
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(O)COC(CCCCCCCCCCCCCCC)=O.[NH4+]
一般說明
溶血磷脂酰肌醇（LPI）是一种生物活性脂质。
應用
16:0 Lyso PI（1-棕榈酰基-2-羟基-sn-甘油-3-磷酸肌醇）已被用作脂质标准品，用于优化液相色谱-质谱（LC-MS）方法条件，并且在溶血磷脂酰肌醇酰基转移酶生化分析中用作溶血磷脂酰肌醇（LPI）底物，以测定肝微粒体的溶血磷脂酰肌醇酰基转移酶（LPIAT）活性。它也可以用作合成的LPI，以比较其在转铁蛋白（Tf）介导的内吞作用下与肝脏LPI的效应。
生化／生理作用
L-α-溶血磷脂酰肌醇（LPI）循环水平的升高与癌症相关，而且LPI是G蛋白偶联受体GPR55的有效配体。
溶血磷脂酰肌醇（LPI）具有调节癌症迁移的能力。它可以控制内皮细胞的功能。LPI可以作为细胞生长的自分泌调节剂，因此已知其参与癌症的进展。它可以刺激信号级联反应，这对于细胞的存活、迁移和增殖至关重要。
包裝
带塞子和压接盖的2 mL棕色血清瓶（850102P-100ug）
带塞子和压接盖的2 mL棕色血清瓶（850102P-500ug）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
No data available
閃點（°C）
No data available
其他客户在看
Emily L Ruban et al.
Biochemical Society transactions, 42(5), 1372-1377 (2014-09-19)
Lysophosphatidylinositol (LPI) is a well-known bioactive lipid that is able to activate signalling cascades relevant to cell proliferation, migration, survival and tumorigenesis. Our previous work suggested that LPI is involved in cancer progression since it can be released in the
Robert N Helsley et al.
eLife, 8 (2019-10-18)
Recent studies have identified a genetic variant rs641738 near two genes encoding membrane bound O-acyltransferase domain-containing 7 (MBOAT7) and transmembrane channel-like 4 (TMC4) that associate with increased risk of non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), alcohol-related cirrhosis, and
Ieva Ailte et al.
Scientific reports, 6, 30336-30336 (2016-07-28)
Shiga toxin (Stx), an AB5 toxin, binds specifically to the neutral glycosphingolipid Gb3 at the cell surface before being transported into cells. We here demonstrate that addition of conical lysophospholipids (LPLs) with large head groups inhibit Stx binding to cells
Mónica Narváez-Rivas et al.
Journal of chromatography. A, 1440, 123-134 (2016-03-02)
The goal of untargeted lipidomics is to have high throughput, yet comprehensive and unambiguous identification and quantification of lipids. Novel stationary phases in LC separation and new mass spectrometric instruments capable of high mass resolving power and faster scanning rate
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