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化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 1 mg (810705P-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand 810705P
應用
lipidomics
脂質類型
coenzymes
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
O[C@@](C(NCCC(NCCSC(CCCCCCCCCCCCCCCNC1=CC=C([N+]([O-])=O)C2=NON=C12)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]3OP([O-])(O)=O)O[C@H]([C@@H]3O)N4C5=C(C(N)=NC=N5)N=C4)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]
InChI
1S/C43H68N11O20P3S.3H3N/c1-43(2,25-70-77(67,68)74-76(65,66)69-24-30-37(72-75(62,63)64)36(57)42(71-30)53-27-50-35-39(44)48-26-49-40(35)53)38(58)41(59)47-21-19-31(55)46-22-23-78-32(56)16-14-12-10-8-6-4-3-5-7-9-11-13-15-20-45-28-17-18-29(54(60)61)34-33(28)51
InChI 密鑰
FBPTUXYEMIFLQO-DNLKZUPMSA-N
一般說明
NBD-棕榈酰-CoA（（N-[（（7-硝基-2-1,3-苯并恶二唑-4-基）-甲基]氨基）棕榈酰辅酶A）是棕榈酰-CoA的荧光类似物。
产品可用于荧光标记蛋白质上的棕榈酰化位点。
應用
16-NBD-16:0辅酶A((N-[（7-硝基-2-1,3-苯并恶二唑-4-基）-甲基]氨基）棕榈酰辅酶A）已用于：
- 作为荧光二酰基甘油酰基转移酶(DGAT)测定中的荧光底物
- 作为荧光类似物，用于研究脂质的膜易位并跟踪棕榈酰-CoA的摄取
- 作为洗涤缓冲液中的组分，用于测量棕榈酸酯转移酶测定中酶的自酰化
生化／生理作用
NBD-棕榈酰-CoA（（N-[（（7-硝基-2-1,3-苯并恶二唑-4-基）-甲基]氨基）棕榈酰辅酶A）可作为放射性示踪剂的经济替代品。
包裝
5 mL琥珀色玻璃螺旋盖小瓶（810705P-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Maurine E Linder et al.
Biochemistry, 42(15), 4311-4320 (2003-04-16)
Since its discovery more than 30 years ago, protein palmitoylation has been shown to have a role in protein-membrane interactions, protein trafficking, and enzyme activity. Until recently, however, the molecular machinery that carries out reversible palmitoylation of proteins has been
S J Moench et al.
Biochemistry, 33(19), 5783-5790 (1994-05-17)
Two tandem cysteine residues in the carboxyl-terminal region of rhodopsin have been shown to be covalently linked to palmitate via thioester bonds (Ovchinnikov, Y. A., et al. (1988) FEBS Lett. 230, 1-5). We have synthesized a fluorescent analogue of palmitoyl
Xiaochao Wei et al.
Cell host & microbe, 11(2), 140-152 (2012-02-22)
The intestinal mucus barrier prevents pathogen invasion and maintains host-microbiota homeostasis. We show that fatty acid synthase (FAS), an insulin-responsive enzyme essential for de novo lipogenesis, helps maintain the mucus barrier by regulating Mucin 2, the dominant mucin in the
Pamela J McFie et al.
Journal of lipid research, 52(9), 1760-1764 (2011-06-10)
Triacylglycerols (TG) are the major storage form of energy in eukaryotic organisms and are synthesized primarily by acyl CoA:1,2-diacylglycerol acyltransferase (DGAT) enzymes. In vitro DGAT activity has previously been quantified by measuring the incorporation of either radiolabeled fatty acyl CoA
Raffaello Verardi et al.
Structure (London, England : 1993), 25(9), 1337-1347 (2017-08-02)
DHHC enzymes catalyze palmitoylation, a major post-translational modification that regulates a number of key cellular processes. There are up to 24 DHHCs in mammals and hundreds of substrate proteins that get palmitoylated. However, how DHHC enzymes engage with their substrates
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