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化驗
>99% (TLC)
形狀
powder
包裝
pkg of 1 × 250 μg (810267P-250ug)
製造商／商標名
Avanti Research™ - A Croda Brand 810267P
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
Glucosyl Ceramide (GlcCer)/cerebroside/galactosylceramide is a neutral, polar lipid. It can be ionized delicately in negative-and positive-ion modes. It is the simplest glycosphingolipids (GSLs), that is present abundantly in the mammalian tissues. GlcCer is produced through glycosylation of Cer with the help of GlcCer synthase (GCS) at the cytosolic leaflet of Golgi apparatus.
應用
C11 TopFluor™ Glucosyl Ceramide is suitable to use as a label in the GLM II model and as a component in the usual giant unilamellar vesicle (GUV) lipid mixture (GLM).
生化／生理作用
Glucosyl ceramide (GlcCer) plays a major role in the pathways of glycosphingolipid metabolism. It helps to modulate cell physiology. It acts as an intracellular messenger in cell maintenance and regulation.
包裝
5 mL Amber Glass Screw Cap Vial (810267P-250ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
Characterization of Lipids by Electrospray Ionization Mass Spectrometry, Lipid Analysis
Lipid analysis (2012)
Effect of glucosylceramide on the biophysical properties of fluid membranes
Varela ARP, et al.
Biochimica et Biophysica Acta - Biomembranes, 1828(3), 1122-1130 (2013)
Omid Motabar et al.
Analytical and bioanalytical chemistry, 402(2), 731-739 (2011-10-29)
Glucocerebrosidase is a lysosomal enzyme that catalyzes the hydrolysis of glucosylceramide to form ceramide and glucose. A deficiency of lysosomal glucocerebrosidase due to genetic mutations results in Gaucher disease, in which glucosylceramide accumulates in the lysosomes of certain cell types.
Lipid segregation and membrane budding induced by the peripheral membrane binding protein annexin A2
Drucker P, et al.
Test, 288(34), 24764-24776 (2013)
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