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化驗
>99% (TLC)
形狀
ethanol solution
包裝
pkg of 1 × 1 mL (810258E-100ug)
製造商／商標名
Avanti Research™ - A Croda Brand 810258E
濃度
0.1 mg/mL (810258E-100ug)
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
C11 TopFluor™ GM3 is a fluorescent analog of ganglioside GM3 (Siaa2-3Galb1-4Glcb1-1Cer).
應用
C11 TopFluor™ GM3 has been used to visualize GM3 present in UGCG-KO1.3 cells by immunofluorescence microscopy.
生化／生理作用
Gangliosides function as modulators in regulating various receptor functions, involved in transmembrane signaling. GM3 plays an important role as a metabolic precursor for the formation of more complex gangliosides. It comprises between 80% and 90% of total ganglioside content in liver and adipose tissue, respectively. Additionally, GM3 is known to promote the subcellular redistribution of major caveolin enriched microdomain (CEM) components coordinating signal transduction. The increased levels of ganglioside GM3 in serum is reported in hyperlipidaemic, hyperglycaemic and type 2 diabetic patients.
包裝
5 mL Amber Glass Screw Cap Vial (810258E-100ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC
訊號詞
Danger
危險聲明
危險分類
Eye Irrit. 2 - Flam. Liq. 2
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
55.4 °F - closed cup
閃點（°C）
13.0 °C - closed cup
Seiichi Tagami et al.
The Journal of biological chemistry, 277(5), 3085-3092 (2001-11-15)
Gangliosides are known as modulators of transmembrane signaling by regulating various receptor functions. We have found that insulin resistance induced by tumor necrosis factor-alpha (TNF-alpha) in 3T3-L1 adipocytes was accompanied by increased GM3 ganglioside expression caused by elevating GM3 synthase
Anshuman Das et al.
Nature microbiology, 5(9), 1069-1078 (2020-05-27)
The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens1. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is
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