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Merck

700133P

Avanti

3β,25-OH-7-oxo-5-cholestenoic acid

Avanti Research - A Croda Brand 700133P, powder

别名:

3β,25-dihydroxy-7-oxo-5-cholestenoic acid

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About This Item

经验公式(希尔记法):
C27H42 O5
分子量:
446.62
UNSPSC代码:
12352211
NACRES:
NA.25

方案

>99% (TLC)

表单

powder

包装

pkg of 1 × 1 mg (700133P-1mg)

制造商/商品名称

Avanti Research - A Croda Brand 700133P

运输

dry ice

储存温度

−20°C

SMILES字符串

O[C@H](C1)CC[C@](C1=C[C@H]2O)(C)C3C2C(CC[C@@H]4[C@H](C)CCCC(C)(O)CO)[C@]4(C)CC3

InChI key

JGEBMCVWDISKRI-MRAVHIDRSA-N

一般描述

3β,25-OH-7-oxo-5-cholestenoic acid is a cholesterol derivative and an oxysterol derived from cholesterol. The synthesis of CA occurs in mitochondria and the enzyme sterol 27-hydroxylase (CYP27A1) catalyzes the step.

生化/生理作用

Cholestenoic acid (CA) serves as a ligand to nuclear receptor and may be neurotoxic or neuroprotective based on their structural features. Defects in the enzymes catalyzing the formation of cholestenoic acids are implicated in disorders related to motor neuron degeneration.

包装

5 mL Amber Glass Screw Cap Vial (700133P-1mg)

法律信息

Avanti Research is a trademark of Avanti Polar Lipids, LLC

储存分类代码

11 - Combustible Solids


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Cholestenoic acid is a prognostic biomarker in acute respiratory distress syndrome.
Jennifer H Madenspacher et al.
The Journal of allergy and clinical immunology, 143(1), 440-442 (2018-10-09)
Peter J Crick et al.
The Journal of steroid biochemistry and molecular biology, 195, 105475-105475 (2019-09-22)
While the presence and abundance of the major oxysterols and cholestenoic acids in the circulation is well established, minor cholesterol metabolites may also have biological importance and be of value to investigate. In this study by observing the metabolism of

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