700022P

7-keto-27-hydroxycholesterol

Avanti Research^™ - A Croda Brand

• 别名: 3β,27-dihydroxy-5-cholesten-7-one
• 经验公式（希尔记法）: C₂₇H₄₄O₃
• CAS号: 240129-30-0
• 分子量: 416.64
• 分類程式碼代碼: 12352211
• NACRES: NA.25

属性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 1 mg (700022P-1mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand
• 運輸包裝: dry ice
• 儲存溫度: −20°C

说明

一般說明

7-keto-27-hydroxycholesterol interconversion to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) is catalyzed by hydroxysteroid 11-β dehydrogenase. It is also formed by the oxidation of 7-oxocholesterol (7-OC) in the presence of enzyme by sterol 26-hydroxylase (CYP27A1).

應用

7-keto-27-hydroxycholesterol has been used as an oxysterol compound to study its interaction with smoothened (SMO) protein, as a substrate to 11β-hydroxysteroid dehydrogenases (11β-HSDs) for kinetic measurement studies,

生化／生理作用

7-keto-27-hydroxycholesterol (7-OC) acts as an agonist for the smoothened (SMO) protein of Hedgehog (Hh) signalling pathway, which is vital for proper cell differentiation in embryonic tissue. It elicits strong affinity to SMO compared to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC). 7-OC is reduced to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) by reactive oxygen species (ROS).

包裝

5 mL Amber Glass Screw Cap Vial (700022P-1mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全信息

• 儲存類別代碼: 11 - Combustible Solids