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Merck

M35304

Sigma-Aldrich

氯甲酸甲酯

99%

别名:

MCF, 氯甲酸甲酯

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About This Item

线性分子式:
ClCOOCH3
CAS号:
分子量:
94.50
Beilstein:
605437
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

蒸汽密度

3.26 (vs air)

品質等級

蒸汽壓力

4.8 psi ( 20 °C)

化驗

99%

自燃溫度

905 °F

折射率

n20/D 1.387 (lit.)

bp

70-72 °C (lit.)

密度

1.223 g/mL at 25 °C (lit.)

儲存溫度

2-8°C

SMILES 字串

COC(Cl)=O

InChI

1S/C2H3ClO2/c1-5-2(3)4/h1H3

InChI 密鑰

XMJHPCRAQCTCFT-UHFFFAOYSA-N

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應用

氯甲酸甲酯(MCF)常用于官能团的衍生化,如羧酸、胺和酚。
MCF还能用于:
  • 活化3-酰基吡啶,用于与炔基锡试剂进行亲核加成,形成2,3-二取代的1,2-二氢吡啶。
  • 末端炔烃的氯酯化反应,形成β-氯-α,β-不饱和酯。
  • 作为亲电试剂,介导吡啶与二烷基锂或二芳基铜酸锂的反应,生成4-取代的1,4-二氢吡啶衍生物。
  • 将硝酸盐转化为甲氧基羰基硝酸盐。

訊號詞

Danger

危險分類

Acute Tox. 2 Inhalation - Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

儲存類別代碼

3 - Flammable liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

50.0 °F - closed cup

閃點(°C)

10 °C - closed cup


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The First Example of Rhodium (I)-Catalyzed Regio-and Stereoselective Chloroesterification of Alkynes with Chloroformate Esters.
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Journal of the American Chemical Society, 120(47), 12365-12366 (1998)
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Phenylethyl alcohol was one of the first quorum sensing molecules (QSMs) identified in C. albicans. This extracellular signalling molecule inhibits the hyphal formation of C. albicans at high cell density. Little is known, however, about the underlying mechanisms by which
Using design of experiments to optimize derivatization with methyl chloroformate for quantitative analysis of the aqueous phase from hydrothermal liquefaction of biomass.
Madsen R B, et al.
Analytical and Bioanalytical Chemistry, 408(8), 2171-2183 (2016)
Reaction of Cuprate Reagents with Pyridine in the Presence of Chloroformate. A Novel Synthesis of 1, 4-Dihydropyridine Derivatives.
Piers E and Soucy M
Canadian Journal of Chemistry, 52(20), 3563-3564 (1974)
Regio-and chemoselective addition of alkynyltin reagents to the 2-position of 3-acylpyridines activated by methyl chloroformate: selective synthesis of 2, 3-disubstituted 1, 2-dihydropyridines.
Yamaguchi R, et al.
Tetrahedron Letters, 29(15), 1785-1788 (1988)

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