937177

Methoxy-poly(ethylene glycol) amine-block-poly-L-lysine hydrobromide

PEG average M_n 2000, PLLA average M_n 10000

• 别名: Block copolymer, Drug delivery polymer, Polymeric micelles, Tissue engineering, Tumor imaging, mPEG-amine2k -PLL10k, mPEGNH₂-PLL
• 线性分子式: C₃H₉NO(OC₂H₄)_x-(C₆H₁₃N₂OBr)_n
• 分類程式碼代碼: 12162002
• NACRES: NA.21

属性

• 形狀: powder or chunks
• 品質等級: 100
• 分子量: PEG average M_n 2000; PLLA average M_n 10000
• 顏色: white to off-white
• 儲存溫度: −20°C

说明

一般說明

Methoxy poly(ethylene glycol) amine-block-poly(L-lysine) (mPEG-PLL) is a cationic diblock copolymer consisting of amine-functionalized PEG and PLL that can be used in drug delivery applications to improve therapeutic efficacy. The cationic PLL block can bind to DNA or RNA, as well as other therapeutic agents, while the amine-functionalized PEG block inhibits protein adsorption and can be further functionalized with targeting moieties for targeted and controlled drug delivery. This cationic diblock copolymer can self-assemble in the presence of a drug to form polymeric micelles and polymersomes.

應用

• Non-viral gene delivery applications
• Targeted drug delivery applications
• Protein coatings and tissue culture

特點和優勢

• Self-assemble capability to form micelles and polymersomes
• Amine functional group at the side chain enables further rapid functionalization
• Cationic poly(L-lysine) has excellent DNA and RNA condensation property
• Biodegradable, biocompatible and water soluble

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable