934429

3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride

≥95%

• 别名: 3-((4-(Piperidin-4-yl)phenyl)amino)piperidine-2,6-dione hydrochloride
• 经验公式（希尔记法）: C₁₆H₂₁N₃O₂ · xHCl
• 分子量: 287.36 (free base basis)
• 分類程式碼代碼: 12352200
• NACRES: NA.21

属性

• 品質等級: 100
• 化驗: ≥95%
• 形狀: powder
• 儲存溫度: 2-8°C
• SMILES 字串: O=C1NC(C(NC2=CC=C(C=C2)C3CCNCC3)CC1)=O.[xHCl]

说明

應用

A functionalized cereblon ligand for development of Thalidomide based PROTACs. Allows rapid conjugation with carboxyl linkers due to presence of amine group via peptide coupling reactions. Amenable for linker attachement via reductive amination, and a basic building block for making protein degrader library.

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其他說明

Targeted Protein Degradation by Small Molecules
Destruction of DNA-Binding Proteins by Programmable Oligonucleotide PROTAC (O′PROTAC): Effective Targeting of LEF1 and ERG
Small-Molecule PROTACS: New Approaches to Protein Degradation
Targeted Protein Degradation: from Chemical Biology to Drug Discovery
Impact of linker length on the activity of PROTACs

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license.

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable