910074

27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid

≥95%

• 别名: 2-2-2-2-2-2-6 PROTAC^® linker, Bifunctional linker, OtBu-PEG₆-acid
• 经验公式（希尔记法）: C₂₃H₄₄O₁₀
• 分子量: 480.59
• 分類程式碼代碼: 12352106

属性

• 化驗: ≥95%
• 形狀: liquid
• 反應適用性: reagent type: linker
• 官能基: carboxylic acid; ester
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(CCCCCCOCCOCCOCCOCCOCCOCC(O)=O)OC(C)(C)C

说明

應用

This heterobifunctional, PEGylated crosslinker 27,27-dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or pproteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.

其他說明

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Partial PROTACs for Targeted Protein Degradation

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable