910058

2-(2-(Oct-7-yn-1-yloxy)ethoxy)acetic acid

≥95%

• 别名: 2-2-6 PROTAC^® linker, Alkyne-PEG₂-acid, Bifunctional linker
• 经验公式（希尔记法）: C₁₂H₂₀O₄
• 分子量: 228.28
• 分類程式碼代碼: 12352106

属性

• 化驗: ≥95%
• 形狀: (Viscous Liquid or Semi-solid or Paste or Solid)
• 反應適用性: reaction type: click chemistry; reagent type: linker
• 官能基: alkyne; carboxylic acid
• 儲存溫度: 2-8°C
• SMILES 字串: OC(COCCOCCCCCCC#C)=O

说明

應用

This heterobifunctional, PEGylated crosslinker 2-(2-(oct-7-yn-1-yloxy)ethoxy)acetic acid features a carboxyl group at one end and an alkyne at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. This alkyne-PEG₂-acid linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation where the linker region is referred to as 2-2-6.

其他說明

Modular PROTAC Design for the Degradation of Oncogenic BCR-ABL

Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable