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779776

Sigma-Aldrich

甲基-β-环糊精

Wacker Chemie AG, ≥95.0% cyclodextrin basis (calculated)

别名:

Cavasol® W7 M

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About This Item

CAS号:
128446-36-6
MDL號碼:
MFCD00066764
分類程式碼代碼:
12352201
NACRES:
NA.22

品質等級

100

化驗

≥95.0% cyclodextrin basis (calculated)

形狀

powder

製造商／商標名

Wacker Chemie AG

標籤範圍

1.6-1.9 molar substitution

雜質

≤0.2% unsubstituted cyclodextrin
≤0.2% volatile organics
≤2% chloride

損耗

≤7.0% loss on drying

mp

180-182 °C (lit.)

SMILES 字串

O1C2OC(C(OC3OC(C(OC4OC(C(OC5OC(C(OC6OC(C(OC7OC(C(OC8OC(C1C(C8OC)O)COC)C(C7OC)O)COC)C(C6OC)O)COC)C(C5OC)O)COC)C(C4OC)O)COC)C(C3OC)O)COC)C(C2OC)O)COC

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3

InChI 密鑰

QGKBSGBYSPTPKJ-UHFFFAOYSA-N

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應用

在单乙醇胺(MEA)存在下，甲基-β-环糊精（M-β-CD）可作为反应物制备双氯芬酸(DCF)三元包合物。该复合物改善了DCF在人体皮肤中的经皮吸收。它也可用于与奥氮平(OLP)形成包合物，用于提高其溶解度，以实现有效的药物递送。

其他說明

仅供R&D使用

法律資訊

Cavasol is a registered trademark of Wacker Chemie AG

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

368.6 °F

閃點（°C）

187 °C

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCD1038
BCCG8208
BCCD4530
BCBZ9133
BCBT9727

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María Julia Mora et al.
European journal of medicinal chemistry, 45(9), 4079-4088 (2010-06-23)
Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-beta-cyclodextrin (M-beta-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state.
Sara Rodríguez-Acebes et al.
The Biochemical journal, 420(2), 305-315 (2009-03-06)
Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is controlled by cholesterol and cholesterol-derived oxysterols. J774 cells cannot convert desmosterol into cholesterol
Mario Menschikowski et al.
Cancer cell international, 11, 4-4 (2011-02-16)
Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of activated protein C (aPC) and anti-apoptotic signalling. This study was carried out
Laurie Hamtiaux et al.
PloS one, 6(10), e26823-e26823 (2011-11-03)
The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenografts. Therefore, we investigated the cytotoxicity
William E Brownell et al.
Pflugers Archiv : European journal of physiology, 461(6), 677-686 (2011-03-05)
Changing the concentration of cholesterol in the plasma membrane of isolated outer hair cells modulates electromotility and prestin-associated charge movement, suggesting that a similar manipulation would alter cochlear mechanics. We examined cochlear function before and after depletion of membrane cholesterol
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