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Merck
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525057

Sigma-Aldrich

4-吡唑硼酸频哪醇酯

97%

别名:

4,4,5,5-四甲基-2-(1H-吡唑-4-基)-1,3,2-二氧杂戊硼烷

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About This Item

线性分子式:
(CH3)4C2O2BC3N2H3
CAS号:
269410-08-4
分子量:
194.04
MDL號碼:
MFCD03453063
分類程式碼代碼:
12352103
PubChem物質ID:
24874465
NACRES:
NA.22

化驗

97%

形狀

solid

mp

142-146 °C (lit.)

SMILES 字串

CC1(C)OB(OC1(C)C)c2cn[nH]c2

InChI

1S/C9H15BN2O2/c1-8(2)9(3,4)14-10(13-8)7-5-11-12-6-7/h5-6H,1-4H3,(H,11,12)

InChI 密鑰

TVOJIBGZFYMWDT-UHFFFAOYSA-N

相关类别

應用

试剂用于
  • Suzuki-Miyaura 交叉耦合
  • 钌催化不对称氢化

用于制备含优势骨架吡唑的许多非常重要的治疗酶和激酶的抑制剂的试剂，包括
  • VEGF
  • 极光
  • Rho（岩石）
  • Janus 激酶 2 (JAK)
  • c-MET
  • ALK
  • S-亚硝基谷胱甘肽还原酶
  • CDC7
  • 乙酰辅酶A羧化酶
  • 促存活 Bcl-2 蛋白
  • 病毒 RNA 依赖性 RNA 聚合酶
  • 长链脂肪酸延长酶 6
  • PI3
  • AKT
  • Chk1
  • 蛋白激酶 B

法律資訊

Boron Molecular 制造

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCQ2654
MKCM6467
MKCL2019
MKCH7974
MKCF8440

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ACS medicinal chemistry letters, 2(10), 720-723 (2011-10-13)
A ligand-based 3D pharmacophore model for serine/threonine kinase CDC7 inhibition was created and successfully applied in the discovery of novel 2-(heteroaryl)-6,7-dihydrothieno[3,2-c]pyridin-4(5H)-ones. The pharmacophore model provided a hypothesis for lead generation missed by docking to a homology model. Medicinal chemistry exploration
Design and evaluation of 3,6-di(hetero)aryl imidazo[1,2-a]pyrazines as inhibitors of checkpoint and other kinases
Matthews, T. P.; et al.
Bioorganic & Medicinal Chemistry, 20, 4045-4049 (2010)
Asymmetric synthesis of potent chroman-based Rho kinase (ROCK-II) inhibitors
Chen, Y-T.; et al.
MedChemComm, 2, 73-75 (2011)
Michael L Curtin et al.
Bioorganic & medicinal chemistry letters, 22(9), 3208-3212 (2012-04-03)
In an effort to identify multi-targeted kinase inhibitors with a novel spectrum of kinase activity, a screen of Abbott proprietary KDR inhibitors against a broad panel of kinases was conducted and revealed a series of thienopyridine ureas with promising activity
Hassan M Shallal et al.
Bioorganic & medicinal chemistry letters, 21(5), 1325-1328 (2011-02-09)
Overexpression of prosurvival or underexpression of pro-death Bcl-2 family proteins can lead to cancer cell resistance to chemotherapy and radiation treatment. Inhibition of the prosurvival Bcl-2 family proteins has become a strategy for cancer therapy and inhibitors are currently being
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