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![三[(1-苄基-1H-1,2,3-三唑-4-基)甲基]胺 97%](/deepweb/assets/sigmaaldrich/product/structures/179/695/86a721c8-2a4c-4e4f-bc36-6276ce7a941f/640/86a721c8-2a4c-4e4f-bc36-6276ce7a941f.png)
品質等級
化驗
≥98%
形狀
solid
mp
162-166 °C (lit.)
官能基
amine
hydrazine
SMILES 字串
Cl.NNC(N)=N
InChI
1S/CH6N4.ClH/c2-1(3)5-4;/h4H2,(H4,2,3,5);1H
InChI 密鑰
UBDZFAGVPPMTIT-UHFFFAOYSA-N
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一般說明
在一项研究中已经报道了氨基胍盐酸盐可作为动物一氧化氮（NO）-合酶的抑制剂。已采用傅立叶和最小二乘法对盐酸氨基胍的晶体结构进行了研究。其晶体为单斜晶体，氨基胍离子的胍部分是平面结构。
應用
氨基胍盐酸盐可作为一氧化氮合酶（NOS）的抑制剂，用于研究其对大鼠结扎性牙周炎牙槽骨损失的影响。它可用于合成5-脒腙衍生物，其具有抗 大肠杆菌 和 金黄色葡萄球菌的抗菌活性。
生化／生理作用
构成型和诱导型一氧化氮合酶两者都抑制。
訊號詞
Warning
危險聲明
危險分類
Aquatic Chronic 2 - Skin Sens. 1B
儲存類別代碼
13 - Non Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
The crystal structure of aminoguanidine hydrochloride.
Bryden JH.
Acta Crystallographica, 10(11), 677-680 (1957)
Lina Nordquist et al.
Advances in experimental medicine and biology, 765, 185-193 (2012-08-11)
Sustained hyperglycemia is closely associated with increased risk to develop nephropathy. We have previously reported alterations in the intrarenal oxygen metabolism already after the early onset of diabetes. Furthermore, formation of advanced glycation end-products (AGE) is postulated as a major
A K Gadad et al.
European journal of medicinal chemistry, 35(9), 853-857 (2000-09-28)
6-Arylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamides 3 on Vilsmeier-Haak reaction produced 5-formyl-6-arylimidazo[2,1-b]-1,3, 4-thiadiazole-2-[N-(dimethylaminomethino)]sulfonamides 4, while 3 on treatment with potassium thiocyanate in the presence of bromine in acetic acid produced 5-thiocyanato-2-sulfonamides 6. Interaction of 4 with aminoguanidine hydrochloride in ethanol produced the corresponding 5-guanylhydrazone derivatives
A K Glyan'ko
Biochemistry. Biokhimiia, 78(5), 471-476 (2013-07-16)
The level of nitric oxide (NO) in roots of 2-day-old etiolated pea (Pisum sativum L.) seedlings was investigated by fluorescence microscopy using the fluorescent probe 4,5-diaminofluorescein diacetate. Segments representing transversal (cross) cuts of the roots having thickness of 100 to
Zahid M Delwar et al.
Cancer research, 78(3), 718-730 (2017-11-10)
The first oncolytic virotherapy employing HSV-1 (oHSV-1) was approved recently by the FDA to treat cancer, but further improvements in efficacy are needed to eradicate challenging refractory tumors, such as glioblastomas (GBM). Microglia/macrophages comprising approximately 40% of a GBM tumor
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