推荐产品
化驗
97%
形狀
solid
mp
121-123 °C (lit.)
SMILES 字串
COc1ccc2[nH]cc(CCN)c2c1
InChI
1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
InChI 密鑰
JTEJPPKMYBDEMY-UHFFFAOYSA-N
基因資訊
human ... HTR1A(3350) , HTR2A(3356) , HTR2C(3358)
rat ... Htr2a(29595) , Htr2c(25187) , Htr7(65032)
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一般說明
5-甲氧色胺（一种褪黑素的代谢物）在人角质细胞中应对紫外B（UVB）的保护性作用已得到研究。
應用
5-甲氧基色胺作为一种激动剂已被用于5-羟色胺1受体的药理作用研究中。
用于制备以下物质的反应物：
- shishijimicin A的咔啉二糖结构域
- 褪黑激素类似物用于降低眼压
- 5-HT4受体配体
- 分选酶A和异柠檬酸裂解酶的抑制剂
- 用于治疗缺血/再灌注（I/R）损伤的治疗剂
- Aurora和表皮生长因子受体激酶抑制剂
- 用于治疗人乳头瘤病毒感染的药剂
- Manzamine类似物用于控制神经炎症和脑部感染
- 促炎细胞因子的抑制剂
- Tacrine-melatonin杂合物作为阿尔茨海默病的多功能药物
包裝
无底玻璃瓶。内含物在插入的融合锥体内。
訊號詞
Warning
危險聲明
危險分類
Acute Tox. 4 Oral
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
Amir Hanna-Elias et al.
European journal of medicinal chemistry, 44(7), 2952-2959 (2009-02-19)
Twenty-three indole-3-methanamines were designed, synthesized and evaluated as ligands for the 5-HT(4) receptor. Compounds I-d, I-j, I-o, I-q and I-u showed good affinity at 100 microM and I-o was found to be only 5-fold less potent than the agonists serotonin
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.
Janjetovic Z, Nahmias ZP, Hanna S, et al.
Journal of Pineal Research, 57(1), 90-102 (2014)
Rut Vleugels et al.
PloS one, 8(5), e65052-e65052 (2013-06-07)
Serotonin (5-hydroxytryptamine, 5-HT) is known for its key role in modulating diverse physiological processes and behaviors by binding various 5-HT receptors. However, a lack of pharmacological knowledge impedes studies on invertebrate 5-HT receptors. Moreover, pharmacological information is urgently needed in
Brian J Prendergast
Endocrinology, 151(2), 714-721 (2009-12-08)
Environmental day length drives nocturnal pineal melatonin secretion, which in turn generates or entrains seasonal cycles of physiology, reproduction, and behavior. In mammals, melatonin (MEL) binds to a number of receptor subtypes including high-affinity (MT1 and MT2) and low-affinity (MT3
R Hardeland
Reproduction, nutrition, development, 39(3), 399-408 (1999-07-27)
Melatonin seems to be an almost ubiquitous substance, which has been detected not only in metazoans, but also in all major non-metazoan taxa investigated, including bacteria, dinoflagellates, euglenoids, trypanosomids, fungi, rhodophyceans, pheophyceans, chlorophyceans and angiosperms. Despite its vast abundance, little
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