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一般說明
The anti-inflammamtory properties and synthesis of carboxylic acid compounds containing benzo-1,4-dioxane (2,3-dihydro-1,4-benzodioxin) subunit was studied.
應用
Benzo-1,4-dioxane (2,3-dihydro-1,4-benzodioxin) was used in the synthesis of stereoisomers which were evaluated as α- and β- adrenergic antagonists.
危險聲明
防範說明
危險分類
Aquatic Chronic 3
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
156.2 °F - closed cup
閃點（°C）
69 °C - closed cup
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
其他客户在看
M T Vázquez et al.
Farmaco (Societa chimica italiana : 1989), 51(3), 215-217 (1996-03-01)
Synthesis and antiinflammatory properties of new carboxylic acids containing the 2,3-dihydro-1,4-benzodioxin subunit are described. The 2-(2,3-dihydro-1, 4-benzodioxin-6-yl)acetic acid was of comparable potency to Ibuprofen, in carrageenan induced rat paw edema assay.
M Khouili et al.
Farmaco (Societa chimica italiana : 1989), 51(3), 185-188 (1996-03-01)
The four stereoisomers of compound 1 were synthesized from 2,3-dihydro-1, 4-benzodioxin and evaluated as alpha- and beta-adrenergic antagonists. Enantiomer 1-b [2R, 2'S] (Figure 1) is the best beta 1-blocking agent. Furthermore all compounds showed a alpha-blocking activity.
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