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Merck

142859

Sigma-Aldrich

二氟乙酸

98%

别名:

1,1-Difluoroacetic acid, 2,2-Difluoroacetic acid

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About This Item

线性分子式:
F2CHCO2H
CAS号:
分子量:
96.03
Beilstein:
1098588
EC號碼:
MDL號碼:
分類程式碼代碼:
12352106
PubChem物質ID:
NACRES:
NA.22

化驗

98%

形狀

liquid

折射率

n20/D 1.344 (lit.)

bp

132-134 °C (lit.)

mp

−1 °C (lit.)

密度

1.526 g/mL at 25 °C (lit.)

官能基

carboxylic acid
fluoro

SMILES 字串

OC(=O)C(F)F

InChI

1S/C2H2F2O2/c3-1(4)2(5)6/h1H,(H,5,6)

InChI 密鑰

PBWZKZYHONABLN-UHFFFAOYSA-N

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相关类别

一般說明

二氟乙酸是一种单羧酸,也是一种有机氟化合物。二氟乙酸是一种易于操作的试剂,用于制备二氟甲基取代基。二氟乙酸可用作直接对杂环化合物进行C−H二氟甲基化的二氟甲基化试剂。

應用

用于在三苯基膦的介导下,由邻位取代苯胺制备 2-二氟化甲基苯并咪唑、-噁唑和-噻唑。

象形圖

CorrosionExclamation mark

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 4 Inhalation - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1A

儲存類別代碼

8A - Combustible corrosive hazardous materials

水污染物質分類(WGK)

WGK 3

閃點(°F)

172.4 °F - closed cup

閃點(°C)

78 °C - closed cup

個人防護裝備

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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N Illy et al.
Comptes rendus des seances de la Societe de biologie et de ses filiales, 175(2), 242-246 (1981-01-01)
Our experiments were carried out in normal and streptozotocin-diabetic rats. The effects of sodium difluoroacetate (DFA) at the dose of 40 mg/kg daily were studied on the blood and retinal lactate levels; these effects were compared to those of an
Brian M Wagner et al.
Journal of chromatography. A, 1489, 75-85 (2017-02-19)
To facilitate mass transport and column efficiency, solutes must have free access to particle pores to facilitate interactions with the stationary phase. To ensure this feature, particles should be used for HPLC separations which have pores sufficiently large to accommodate
Tetrahedron Letters, 48, 3251-3251 (2007)
J N Commandeur et al.
Biochemical pharmacology, 37(23), 4495-4504 (1988-12-01)
The biotransformation and the hepato- and nephrotoxicity of the mercapturic acids (N-acetyl-1-cysteine S-conjugates) of three structurally related 2,2-difluoroethylenes were investigated in vivo in the rat. All mercapturic acids appeared to cause nephrotoxicity, without any measureable effect on the liver. The
Ute Dorgerloh et al.
Molecules (Basel, Switzerland), 24(6) (2019-03-17)
The concentrations of difluoroacetic acid (DFA) and trifluoroacetic acid (TFA) in rainwater and surface water from Berlin, Germany resembled those reported for similar urban areas, and the TFA/DFA ratio in rainwater of 10:1 was in accordance with the literature. In

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