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Merck

139181

Sigma-Aldrich

溴二氯甲烷

≥97%

别名:

二氯溴甲烷

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About This Item

线性分子式:
BrCHCl2
CAS号:
分子量:
163.83
Beilstein:
1697005
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

≥97%

形狀

liquid

包含

potassium carbonate as stabilizer

折射率

n20/D 1.497 (lit.)

bp

87 °C (lit.)

mp

−55 °C (lit.)

溶解度

water: insoluble

密度

1.98 g/mL at 25 °C (lit.)

官能基

bromo

SMILES 字串

ClC(Cl)Br

InChI

1S/CHBrCl2/c2-1(3)4/h1H

InChI 密鑰

FMWLUWPQPKEARP-UHFFFAOYSA-N

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應用

溴二氯甲烷用于研究“氯二溴甲烷、溴二氯甲烷和溴仿在小鼠体内”的遗传毒性。

生化/生理作用

溴二氯甲烷 (BDCM) 诱导人肝脏脂肪性肝炎损伤。BDCM在雄性F344大鼠中通过肾小管细胞增殖诱导不同组织的细胞增殖和肾损害

訊號詞

Danger

危險分類

Acute Tox. 4 Oral - Carc. 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

10 - Combustible liquids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Chlorination of drinking water results in the formation of chlorodibromomethane, bromodichloromethane and bromoform. These trihalomethanes have all shown evidence of genotoxicity in bacterial and mammalian cell systems in vitro and some evidence of carcinogenicity in rodents. Chlorodibromomethane and bromodichloromethane have
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American journal of physiology. Gastrointestinal and liver physiology, 305(12), G950-G963 (2013-10-26)
Recent studies indicate that metabolic oxidative stress, autophagy, and inflammation are hallmarks of nonalcoholic steatohepatitis (NASH) progression. However, the molecular mechanisms that link these important events in NASH remain unclear. In this study, we investigated the mechanistic role of purinergic
Ted Lock et al.
Archives of toxicology, 78(7), 410-417 (2004-05-14)
Male F344 rats exposed to bromodichloromethane (BDCM) by gavage at 50 or 100 mg/kg/day for 5 days a week for 28 days excreted large amounts of formic acid in their urine, which was accompanied by a change in urinary pH.
Regina Grazuleviciene et al.
Occupational and environmental medicine, 70(4), 274-282 (2013-02-14)
Congenital anomalies have been inconsistently associated with maternal crude estimated exposure to drinking water trihalomethane (THM). We investigated the relationship between individual THM uptake during the first trimester of pregnancy and congenital anomalies. We estimated maternal THM uptake for 3074
Teresa L Leavens et al.
Toxicological sciences : an official journal of the Society of Toxicology, 99(2), 432-445 (2007-07-28)
Exposure to bromodichloromethane (BDCM), one of the most prevalent disinfection byproducts in drinking water, can occur via ingestion of water and by dermal absorption and inhalation during activities such as bathing and showering. The objectives of this research were to

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