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化驗
97%
形狀
solid
expl. lim.
22 %
bp
315 °C (lit.)
mp
48-50 °C (lit.)
溶解度
alcohol: soluble (hot)
alcohol: very slightly soluble (cold)
benzene: soluble
carbon disulfide: soluble
diethyl ether: soluble
water: insoluble
官能基
chloro
SMILES 字串
[O-][N+](=O)c1ccc(Cl)c(c1)[N+]([O-])=O
InChI
1S/C6H3ClN2O4/c7-5-2-1-4(8(10)11)3-6(5)9(12)13/h1-3H
InChI 密鑰
VYZAHLCBVHPDDF-UHFFFAOYSA-N
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應用
1-氯代-2,4-二硝基苯用于逆相HPLC检测人体组织中单个谷胱甘肽S转移酶亚基相对含量。它可作为接触敏化剂,研究抗菌肽链hBD-2,-3和-4以及LL-37诱导的人角质细胞 IL-18蛋白质释放。
生化/生理作用
2,4-二硝基氯代笨诱发BALB/c小鼠模型特应性皮炎。
準備報告
当作为谷胱甘肽S转移酶底物时,将该产品溶于乙醇,然后加入缓冲溶液,形成终浓度为1mM的磷酸盐缓冲液 (8 mL 0.2M KH2PO4和28ml 0.1M Na2HPO4每100ml溶液,调节到pH6.5)4%(v/v)乙醇。
訊號詞
Danger
危險分類
Acute Tox. 2 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1
儲存類別代碼
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
水污染物質分類(WGK)
WGK 2
閃點(°F)
381.2 °F - closed cup
閃點(°C)
194 °C - closed cup
個人防護裝備
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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This study investigates Bisphenol A (BPA) induced oxidative stress that mediates the genotoxicity in in vivo model Drosophila melanogaster. The calculated LC50 for BPA was 12.35 μg/mL. The strains of D. melanogaster were reared in 0.1, 1.0, 2.5 and 5.0 μg/mL BPA
Journal of immunology (Baltimore, Md. : 1950), 175(3), 1776-1784 (2005-07-22)
In addition to its physical barrier against invading microorganisms, the skin produces antimicrobial peptides, human beta-defensins (hBDs) and cathelicidin LL-37, that participate in the innate host defense. Because IL-18 is produced by keratinocytes and involved in skin diseases in which
Archives of toxicology, 87(4), 763-766 (2012-11-13)
Several in vitro DNA microarray studies have shown the importance of nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skin sensitization. Nevertheless, the exact in vivo role of the Nrf2-Keap1 pathway during the induction of skin sensitization remains unknown. To study
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