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Merck

128775

Sigma-Aldrich

4-羟基哌啶

98%

别名:

4-哌啶醇

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About This Item

经验公式(希尔记法):
C5H11NO
CAS号:
分子量:
101.15
Beilstein:
102738
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

98%

bp

108-114 °C/10 mmHg (lit.)

SMILES 字串

OC1CCNCC1

InChI

1S/C5H11NO/c7-5-1-3-6-4-2-5/h5-7H,1-4H2

InChI 密鑰

HDOWRFHMPULYOA-UHFFFAOYSA-N

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一般說明

研究了4-羟基哌啶的分子结构、振动光谱、NBO和紫外光谱分析。已经发现具有取代的4-哌啶醇核心的化合物是人H(3)受体的有效拮抗剂

應用

4-羟基哌啶(4-哌啶醇)可用于合成高效、高选择性的IP(PGI(2) 受体)激动剂。它也可用于研究铜催化的N-芳基化和O-芳基化作用。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Eye Irrit. 2 - Skin Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


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分析证书(COA)

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N- versus O-arylation of aminoalcohols: orthogonal selectivity in copper-based catalysts.
Alexandr Shafir et al.
Journal of the American Chemical Society, 129(12), 3490-3491 (2007-03-08)
James T Anderson et al.
Bioorganic & medicinal chemistry letters, 20(21), 6246-6249 (2010-09-14)
Compounds containing a substituted 4-piperidinol core have been found to be potent antagonists of the human H(3) receptor. The compounds exhibited up to a 60-fold preference for inhibiting the human H(3) receptor over the mouse and showed a low binding
S Sebastian et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 75(3), 941-952 (2010-01-09)
In this work, we report a combined experimental and theoretical study on molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine (4-HP). The FT-IR solid phase (4000-400 cm(-1)), FT-IR gas phase (5000-400 cm(-1)) and FT-Raman spectra (3500-50 cm(-1)) of
Yasuhiro Morita et al.
Molecules (Basel, Switzerland), 17(2), 1233-1246 (2012-02-02)
An efficient synthesis of a highly potent and selective IP (PGI(2) receptor) agonist that is not structurally analogous to PGI(2) is described. This synthesis is accomplished through the following key steps: Nucleophilic ring-opening of 3-(4-chlorophenyl)-oxazolidin-2-one prepared by a one-pot procedure

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