RAB0283
Human IL-1ra ELISA Kit
for serum, plasma, cell culture supernatant and urine
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About This Item
UNSPSC Code:
41116158
NACRES:
NA.84
Recommended Products
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type serum
sample type cell culture supernatant(s)
sample type plasma
sample type urine
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 100 pg/mL
standard curve range: 0.124-30 ng/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... IL1RN(3557)
General description
The Human IL-1ra ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human IL-1ra in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Human IL-1 Receptor Antagonist
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Interleukin-1 receptor antagonist (IL-1RA) inhibits the activity of IL-1α and IL-1β by competitively binding to their type I and type II receptors. IL-1RA plays a vital role in inhibition of acute pro-inflammatory response and forbidding chronic inflammation from damaging healthy tissues. Abnormal expression of IL-1RA leads to development of inflammatory or autoimmune related diseases. Allelic polymorphism of IL-1RA leads to inflammatory bowel disease (IBD). Therapeutically, IL-1RA may help in the treatment of sepsis, rheumatoid arthritis, asthma. Overexpression of IL-1RA is observed in serum of psoriatic arthritis (PsA) patients.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Kit Components Also Available Separately
Product No.
Description
SDS
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
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Relationship of plasma leptin to plasma cytokines and human survivalin sepsis and septic shock.
Arnalich F
The Journal of Infectious Diseases, 180(3), 908-911 (1999)
A novel association between IL1-Ra (receptor antagonist) gene polymorphism and T1DM in Al-Madina Al-Mounawra.
Ali RA
European Review for Medical and Pharmacological Sciences, 19(19), 3701-3708 (2015)
Allelic polymorphism in IL-1 beta and IL-1 receptor antagonist (IL-1Ra) genes in inflammatory bowel disease.
Bioque G
Clinical and Experimental Immunology, 102(2), 379-383 (1995)
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.
Bresnihan B
Arthritis and Rheumatism, 41(12), 2196-2204 (1998)
Serum levels of IL-10, IL-6, IL-1ra, and sIL-2R in patients with psoriatic arthritis.
Elkayam O
Rheumatology International, 19(3), 101-105 (2000)
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