Skip to Content
Merck
All Photos(3)

Key Documents

More Documents

F9677

Sigma-Aldrich

Felodipine

solid

Synonym(s):

4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester, Plendil

Sign Into View Organizational & Contract Pricing
All Photos(3)

About This Item

Empirical Formula (Hill Notation):
C18H19NO4Cl2
CAS Number:
72509-76-3
Molecular Weight:
384.25
MDL number:
MFCD00868316
UNSPSC Code:
12352200
PubChem Substance ID:
24278449

form

solid

Quality Level

200

solubility

DMSO: 20 mg/mL
H2O: insoluble

originator

AstraZeneca

SMILES string

CCOC(=O)C1=C(C)NC(C)=C(C1c2cccc(Cl)c2Cl)C(=O)OC

InChI

1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3

InChI key

RZTAMFZIAATZDJ-UHFFFAOYSA-N

Gene Information

human ... CACNA1C(775) , CACNA1D(776) , CACNA1F(778) , CACNA1S(779) , CACNA2D1(781) , NR3C2(4306)

Looking for similar products? Visit Product Comparison Guide

General description

Felodipine is a dihydropyridine derivative. It has diuretic properties. Felodipine has high vascular selectivity. It is used to treat hypertension. Felodipine regulates chronic stable angina.

Biochem/physiol Actions

L-type calcium channel blocker

Features and Benefits

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Signal Word

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 2 - STOT RE 2 Inhalation

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Haiyan Li et al.
International journal of pharmaceutics, 427(2), 270-275 (2012-03-01)
Tomographic imaging techniques are attractive tools for the visualization of the internal structural characteristics of pharmaceutical solid dosage forms. In this paper, the internal structure of the tablet core for a monolith osmotic drug delivery system, felodipine sustained-release tablet, was
Marianne Dybdahl et al.
Toxicology and applied pharmacology, 262(3), 301-309 (2012-05-26)
The pregnane X receptor (PXR) has a key role in regulating the metabolism and transport of structurally diverse endogenous and exogenous compounds. Activation of PXR has the potential to initiate adverse effects, causing drug-drug interactions, and perturbing normal physiological functions.
Nikolaos Scoutaris et al.
Journal of materials science. Materials in medicine, 23(2), 385-391 (2011-11-16)
Three different formulations comprising two drugs, felodipine and hydrochlorothiazide (HCT) and two polymers, poly(vinyl pyrolidone) (PVP) and poly(lactic-co-glycolic acid) (PLGA) were inkjet printed as micro-dot arrays and analysed on an individual micro-spot basis by time-of-flight secondary ion mass spectrometry (ToF-SIMS).
Emilie Hénin et al.
The AAPS journal, 14(2), 155-163 (2012-01-31)
Absorption models used in the estimation of pharmacokinetic drug characteristics from plasma concentration data are generally empirical and simple, utilizing no prior information on gastro-intestinal (GI) transit patterns. Our aim was to develop and evaluate an estimation strategy based on
Yuqing Zhang et al.
Journal of hypertension, 30(11), 2202-2212 (2012-09-20)
In antihypertensive treatment trials, when randomized therapies do not reach target, additional drugs are administered. However, patients requiring (add-on) or not requiring add-on therapy (no-add-on) may be at different cardiovascular risk and differently susceptible to benefits of antihypertensive treatment. The
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service