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P8615

Sigma-Aldrich

Phosphoinositide 3-kinase p110γ human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

Synonym(s):

PI3K p110γ human, Phosphatidylinositol 3-kinase p110γ human

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About This Item

MDL number:
MFCD03457993
UNSPSC Code:
12352207
NACRES:
NA.32

recombinant

expressed in baculovirus infected insect cells

Quality Level

200

Assay

≥95% (SDS-PAGE)

form

buffered aqueous glycerol solution

specific activity

~4.5 units/mg protein

UniProt accession no.

P48736

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... PIK3CG(5294)

General description

Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.

Biochem/physiol Actions

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.
Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.
PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.

Unit Definition

1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.

Physical form

Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

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Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism
Serajee FJ, et al.
Journal of medical Genetics, 40 (2003)
Down-Regulation of PIK3CG, a Catalytic Subunit of Phosphatidylinositol 3-OH Kinase, by CpG Hypermethylation in Human Colorectal Carcinoma
Semba S, et al.
Clinical Cancer Research, 8, 3824-3831 (2002)
Genome-wide meta-analyses identifies 7 loci associated with platelet aggregation in response to agonists
Johnson AD, et al.
Nature Genetics, 42, 608-613 (2010)
The effect of pharmacological PI3Kγ inhibitor on eotaxin-induced human eosinophil functions.
Saito Y, et al.
Pulmonary Pharmacology & Therapeutics, 27, 164-169 (2014)
D Leopoldt et al.
The Journal of biological chemistry, 273(12), 7024-7029 (1998-04-18)
Class I phosphoinositide 3-kinases (PI3Ks) regulate important cellular processes such as mitogenesis, apoptosis, and cytoskeletal functions. They include PI3Kalpha, -beta, and -delta isoforms coupled to receptor tyrosine kinases and a PI3Kgamma isoform activated by receptor-stimulated G proteins. This study examines
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