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Key Documents

MABN668

Sigma-Aldrich

Anti-Ly6C Antibody, clone 6C3

clone 6C3, from rat

Synonym(s):

Lymphocyte antigen 6C2, Ly-6C2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rat

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

6C3, monoclonal

species reactivity

mouse

technique(s)

dot blot: suitable
flow cytometry: suitable

isotype

IgG2aκ

NCBI accession no.

NP_001092687

UniProt accession no.

P0CW03

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Ly6C1(17067)

General description

Lymphocyte antigen 6C2 (Ly6C) is a 131 AA long membrane protein that is linked to macrophage phenotype according to expression levels.

Immunogen

Whole cells expressing mouse Ly6C.

Application

Detect Lymphocyte antigen 6C2 using this rat monoclonal antibody, Anti-Ly6C Antibody, clone 6C3 validated for use in Flow Cytometry & Dot Blot.
Dot Blot Analysis: A representative lot from an independent laboratory detected Ly6C in bone marrow-derived monocytes expressing 6C3 (Butovsky, O., et al. (2012). J Clin Invest. 122(9):3063-3087.).
Research Category
Neuroscience
Research Sub Category
Signaling Neuroscience

Quality

Evaluated by Flow Cytometry in mouse spleen cells.

Flow Cytometry Analysis: 1 µg of this antibody detected Ly6C in 1X10E6 mouse spleen cells.

Target description

14 kDa calculated

Physical form

Format: Purified
Protein G Purified
Purified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Zhilong Jiang et al.
Respiratory research, 18(1), 217-217 (2017-12-30)
SOCS3 (suppressor of cytokine signaling 3) is a negative regulator of JAK/STAT3 signaling pathway and participates in the regulation of lung inflammation in a mouse model with acute lung injury (ALI). However, it is not well understood how SOCS3 regulates
Qin Huang et al.
PloS one, 14(11), e0225206-e0225206 (2019-11-15)
The engineered AAV-PHP.B family of adeno-associated virus efficiently delivers genes throughout the mouse central nervous system. To guide their application across disease models, and to inspire the development of translational gene therapy vectors for targeting neurological diseases in humans, we
Oleg Butovsky et al.
The Journal of clinical investigation, 122(9), 3063-3087 (2012-08-07)
Amyotrophic lateral sclerosis (ALS) is a progressive disease associated with neuronal cell death that is thought to involve aberrant immune responses. Here we investigated the role of innate immunity in a mouse model of ALS. We found that inflammatory monocytes

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