900917
N-Azidoacetylmannosamine-tetraacylated
95%
Synonym(s):
Ac4ManNAz
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About This Item
Empirical Formula (Hill Notation):
C16H22N4O10
CAS Number:
Molecular Weight:
430.37
UNSPSC Code:
12352116
NACRES:
NA.22
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Quality Level
Assay
95%
form
powder or crystals
reaction suitability
reaction type: click chemistry
storage temp.
−20°C
Related Categories
Application
N-Azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an azide-containing metabolic glycoprotein labeling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
Tetraacylated N-azidoacetylmannosamine is generally used in click chemistry applications in bioconjugate chemistry.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Shajahan A, et al.
Journal of the American Chemical Society, 139(2), 693-700 (2017)
Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.
Jewett J C, et al.
Journal of the American Chemical Society, 132(11), 3688-3690 (2010)
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