Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.

Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors.

Molecular pharmacology (2017-04-01)

Anja Probst Larsen, Sabine Fièvre, Karla Frydenvang, Pierre Francotte, Bernard Pirotte, Jette Sandholm Kastrup, Christophe Mulle

PMID28360094

ABSTRAKT

Kainate receptors (KARs) consist of a class of ionotropic glutamate receptors, which exert diverse pre- and postsynaptic functions through complex signaling regulating the activity of neural circuits. Whereas numerous small-molecule positive allosteric modulators of the ligand-binding domain of (