Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor.

Catalytic asymmetric total synthesis of (S)-(-)-zearalenone, a novel lipoxygenase inhibitor.

Bioorganic & medicinal chemistry (2013-07-23)

Marc P Baggelaar, Yange Huang, Ben L Feringa, Frank J Dekker, Adriaan J Minnaard

ABSTRAKT

A catalytic asymmetric synthesis of (S)-(-)-zearalenone is reported using asymmetric allylic alkylation for the introduction of the stereocenter. (S)-(-)-Zearalenone turned out to be a novel lipoxygenase inhibitor.

MATERIAŁY

Numer produktu

Marka

Opis produktu

L6632

Sigma-Aldrich

Lipoxidase from Glycine max (soybean), Type V, ammonium sulfate suspension, 500,000-1,000,000 units/mg protein

L7395

Sigma-Aldrich

Lipoxidase from Glycine max (soybean), Type I-B, lyophilized powder, ≥50,000 units/mg solid