- [Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].
[Influence of fluoxetine and paroxetine on anxiety-like behavior in young and adult prenatally stressed male rats].
Patologicheskaia fiziologiia i eksperimental'naia terapiia (2014-03-20)
N E Ordyan, S G Pivina, Yu O Fedotova, V K Akulova
PMID24640778
ABSTRAKT
The aim of the present work was an estimation of effects of chronic administration of selective serotonin reuptake inhibitors--fluoxetine (5.0 mg/kg, p.o.) and paroxetine (5.0 mg/kg, p.o.) for 14 days of postnatal period on anxiety-like behavior in the prenatally stressed male rats during pubertal period (1,5 month) and the adult state (3 month). Chronic paroxetine administration to females failed to change an anxiety-like behavior independently from age. On the contrary, administration of fluoxetine resulted in modulating influence on the anxiety-like behavior of prenatally stressed rats dependently from age: anxiolytic effect was noted in young males, while anxiogenic effect was observed in the adult male rats.
MATERIAŁY
Numer produktu
Marka
Opis produktu
Paroxetine hydrochloride (anhydrous), European Pharmacopoeia (EP) Reference Standard