Przejdź do zawartości
Merck

Stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc), a new potent hexosaminidase inhibitor.

Organic letters (2013-06-27)
Alex de la Fuente, Ruben Martin, Teresa Mena-Barragán, Xavier Verdaguer, José M García Fernández, Carmen Ortiz Mellet, Antoni Riera
ABSTRAKT

A practical synthesis of the previously unreported N-acetyl-D-allosamine glycomimetic DAJNAc is described. The reaction sequence involves Pd-catalyzed allylic substitution by phthalimide in an azaheterobicyclic scaffold as the key step. The new iminosugar resulted in being a stronger β-N-acetylglucosaminidase (human placenta) competitive inhibitor than the D-gluco (DNJNAc) and D-galacto (DGJNAc) stereoisomers.

MATERIAŁY
Numer produktu
Marka
Opis produktu

Supelco
1-Deoxynojirimycin, analytical standard