- Cytotoxic constituents of the stem bark of Neolitsea acuminatissima.
Cytotoxic constituents of the stem bark of Neolitsea acuminatissima.
Journal of natural products (2002-03-23)
Fang-Rong Chang, Tian-Jye Hsieh, Ti-Lung Huang, Chung-Yi Chen, Reen-Yen Kuo, Yuh-Chwen Chang, Hui-Fen Chiu, Yang-Chang Wu
PMID11908960
ABSTRAKT
Three new eudesmanolide sesquiterpenes, neolitacumone A-C (1-3), and one new benzylisoquinoline alkaloid, neolitacumonine (5), along with 27 known compounds were isolated from the stem bark of Neolitsea acuminatissima. The structures of compounds 1-3 and 5 were established on the basis of spectral and chemical evidence. Compounds 2, 3, and 20 were selectively inhibitory to Hep 2,2,15 cells with IC50 values in the range 0.24-0.04 microg/mL. Compound 20 was marginally cytotoxic to Hep G2 cells.
MATERIAŁY