- Monooxygenation of N-acetylhistamine mediated by L-ascorbate.
Monooxygenation of N-acetylhistamine mediated by L-ascorbate.
Biochimica et biophysica acta (1989-05-31)
K Uchida, M Mitsui, S Kawakishi
PMID2719978
ABSTRAKT
In the presence of molecular oxygen and a catalytic amount of copper(II) ion, ascorbate almost completely degraded histamine (approx. 72%). The reaction was shown to occur at the imidazole group but not at the primary amino group in histamine. 4-[2-(Acetylamino)ethyl]-2,3-dihydroimidazol-2-one, a monooxygenated form of N-acetylhistamine, was first isolated as the primary product.
MATERIAŁY