P5333

Pleiotrophin human

≥97% (SDS-PAGE), recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture

• Synonim(y): HARP, HB-GAM, Heparin affinity regulatory peptide, Heparin-binding growth factor, Heparin-binding growth-associated molecule, PTN
• Numer MDL: MFCD01324256
• Kod UNSPSC: 12352202
• NACRES: NA.32

Właściwości

• pochodzenie biologiczne: human
• Poziom jakości: 200
• rekombinowane: expressed in baculovirus infected Sf21 cells
• Próba: ≥97% (SDS-PAGE)
• Formularz: lyophilized powder
• masa cząsteczkowa: predicted mol wt 15.3 kDa
• opakowanie: pkg of 50 μg
• warunki przechowywania: avoid repeated freeze/thaw cycles
• metody: cell culture | mammalian: suitable
• zanieczyszczenia: endotoxin, tested
• numer dostępu UniProt: P21246
• temp. przechowywania: −20°C
• informacje o genach: human ... PTN(5764)

Opis

Opis ogólny

Pleiotrophin (PTN) is a multifunctional growth factor. The protein coded by the PTN gene is a member of the heparin-binding cytokines family. This gene is located on human chromosome 7. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). This gene is highly expressed in brain, uterus, gut, muscle, lung and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, tumor cells, fibroblasts, astrocytes and Schwann cells.

Zastosowanie

PTN is active in growth and development, and has mitogenic and neurite outgrowth activity. The gene for pleiotrophin is highly expressed in brain, uterus, gut, muscle, lung, and skin tissues

Działania biochem./fizjol.

Pleiotrophin may be the first member of a family of developmentally regulated cytokines. It is active in growth and development and the pleiotrophin gene is highly expressed in brain, uterus, gut, muscle, lung, and skin. Pleiotrophin mRNA is expressed in osteoblasts, chondrocytes, fibroblasts, astrocytes, Schwann cells, and tumor cells. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. Pleiotrophin is also known as heparin-binding brain mitogen (HBBM), heparin-binding growth factor-8 (HBGF-8), heparin-binding growth-associated molecule (HB-GAM) and osteoblast-specific factor (OSF-1). There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.

Pleiotrophin participates in growth and development. Pleiotrophin is mitogenic and displays neurite outgrowth activity. It stimulates tumor angiogenesis. There is extraordinary conservation between the amino acid sequences of bovine, human, and rat pleiotrophin.

Postać fizyczna

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.

Komentarz do analizy

The activity is measured in culture by the ability to enhance neurite outgrowth of cerebral cortical neurons from rat embryos.

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Informacja o środkach bezpieczeństwa

• Kod klasy składowania: 11 - Combustible Solids
• Klasa zagrożenia wodnego (WGK): WGK 2
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable
• Środki ochrony indywidualnej: Eyeshields, Gloves, type N95 (US)