14-595-M
PP1α Protein, 10 µg
Recombinant, full length, human PP1α, for use in Phosphatase Assays.
Synonim(y):
PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase
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About This Item
Kod UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.32
Polecane produkty
pochodzenie biologiczne
human
Poziom jakości
rekombinowane
expressed in E. coli
Postać
solution
okres trwałości
6 mo.
masa cząsteczkowa
Mw 37.6 kDa
producent / nazwa handlowa
Upstate®
metody
activity assay: suitable (phosphatase)
rozpuszczalność
water: soluble
numer dostępu NCBI
numer dostępu UniProt
temp. przechowywania
−20°C
informacje o genach
human ... PPP1CA(5499)
Opis ogólny
Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Zastosowanie
Research Category
Inflammation & Immunology
Inflammation & Immunology
Działania biochem./fizjol.
Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Opakowanie
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.
Jakość
routinely evaluated by dephosphorylation of 100μM DiFMUP
Postać fizyczna
Heparin agarose followed by Q agarose
Przechowywanie i stabilność
6 months at -20°C from date of shipment
Inne uwagi
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Informacje prawne
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Oświadczenie o zrzeczeniu się odpowiedzialności
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Hasło ostrzegawcze
Warning
Zwroty wskazujące rodzaj zagrożenia
Zwroty wskazujące środki ostrożności
Klasyfikacja zagrożeń
Skin Sens. 1
Kod klasy składowania
12 - Non Combustible Liquids
Klasa zagrożenia wodnego (WGK)
WGK 1
Certyfikaty analizy (CoA)
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Dokumenty związane z niedawno zakupionymi produktami zostały zamieszczone w Bibliotece dokumentów.
The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
Hugo Ceulemans et al.
Physiological reviews, 84(1), 1-39 (2004-01-13)
The protein serine/threonine phosphatase protein phosphatase-1 (PP1) is a ubiquitous eukaryotic enzyme that regulates a variety of cellular processes through the dephosphorylation of dozens of substrates. This multifunctionality of PP1 relies on its association with a host of function-specific targetting
Patricia T W Cohen
Journal of cell science, 115(Pt 2), 241-256 (2002-02-13)
Protein phosphatase 1 (PP1) is a major eukaryotic protein serine/threonine phosphatase that regulates an enormous variety of cellular functions through the interaction of its catalytic subunit (PP1c) with over fifty different established or putative regulatory subunits. Most of these target
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