E2F4
E2F transcription factor 4, p107/p130-binding
Synonimy:
E2F-4
Gatunek:
Human E2F4 (1874), Mouse E2f4 (104394), Rat E2f4 (100360427), Zebrafish e2f4 (406741), chicken E2F4 (769430), dog E2F4 (611243), cow E2F4 (525428), domestic cat E2F4 (101098911), sheep E2F4 (101106963), naked mole-rat E2f4 (101716696)
Identyfikator UniProtKB:
Identyfikator genu:
- Human(1874) Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
- Mouse(104394) E2F transcription factor 4
- Rat(100360427) E2F transcription factor 4, p107/p130-binding
- Zebrafish(406741) E2F transcription factor 4
- chicken(769430) E2F transcription factor 4, p107/p130-binding
- dog(611243) E2F transcription factor 4, p107/p130-binding
- cow(525428) E2F transcription factor 4, p107/p130-binding
- domestic cat(101098911) E2F transcription factor 4, p107/p130-binding
- sheep(101106963) E2F transcription factor 4, p107/p130-binding
- naked mole-rat(101716696) E2F transcription factor 4, p107/p130-binding
- domestic guinea pig(100735380) E2F transcription factor 4, p107/p130-binding
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Antibodies
Numer produktu
Opis
Reaktywność gatunkowa
Zastosowanie
Monoclonal Anti-E2F4 antibody produced in mouse, clone 5B7, purified immunoglobulin, buffered aqueous solution,
Reaktywność gatunkowa
human
Zastosowanie
ELISA
western blot
western blot
Anti-E2F4 antibody produced in rabbit, affinity isolated antibody,
Reaktywność gatunkowa
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat
Zastosowanie
immunohistochemistry
western blot
western blot
Przeciwciało anty-E2F4, klon 3O6Y9, królicze monoklonalne, ,
Reaktywność gatunkowa
mouse
Zastosowanie
western blot
Anty-E2F4, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reaktywność gatunkowa
human
Zastosowanie
immunofluorescence
Anti-E2F4 Antibody, clone LLF4-2, clone LLF4-2, from mouse,
Reaktywność gatunkowa
human, mouse
Zastosowanie
immunohistochemistry
western blot
western blot